Pharmacogenomics of
cyclooxygenases. Pharmacogenomics 2015; 16: 501-522, doi: 10.2217/pgs.15.6.
This might be due to non-selective inhibition of
cyclooxygenases that provides support in the synthesis of prostanoids necessary for generating signals by APCs (Antigen presenting cells) and transmitting these signals to T cells.
Willoughby, Inducible
cyclooxygenase may have anti-inflammatory properties, Nature Medicine, 5(6), 698-701 (1999).
Lin et al., "Specific inhibition of
cyclooxygenase 2 restores antitumor reactivity by altering the balance of IL-10 and IL-12 synthesis," Journal of Immunology, vol.
Structurally, the two
cyclooxygenase enzymes, COX1 and COX-2, are homodimers of two 70kDa subunits related by a C2 axis of symmetry.
Regional expression of
cyclooxygenase isoforms in the rat kidney in complete unilateral ureteral obstruction.
Effects of the
Cyclooxygenase inhibitor, Piroxican, on tumor response, apoptosis, and angiogenesis in a canine model of human invasive urinary bladder cancer.
In vitro studies were performed to determine the inhibitory benefits of Metabiotics Resveratrol on a full thickness tissue model to reduce expression of the anti-inflammatory enzyme
cyclooxygenase 1 [COX1] along with its ability to promote the synthesis of Collagen IVA on the same tissue model.