The
dopamine hypothesis of schizophrenia proposes that overactivity of mesolimbic DA neurons cause the positive symptoms, where underactivity of mesocortical DA neurons cause the negative, cognitive, and affective symptoms of schizophrenia.
Compared to the previous versions of the
dopamine hypothesis, the sociodevelopmental-cognitive model suggests that dopamine dysfunction accounts not only for delusions but also for hallucinations and negative symptoms, such as apathy and a motivation.
The
dopamine hypothesis of stuttering and its treatment implications.
The
dopamine hypothesis of drug addiction and its potential therapeutic value.
As a cause of schizophrenia, 3 hypotheses are advocated:
dopamine hypothesis, glutamate hypothesis, and neurodevelopmental disorder hypothesis.
It was around the time of this recognized failure that the one researcher made the first formal articulation of the
dopamine hypothesis of schizophrenia (Rossum, 1966).
Seeman, "Dopamine receptors and the
dopamine hypothesis of schizophrenia," Synapse, vol.
Neuropharmacology of second-generation antipsychotic drugs: a validity of the serotonin -
dopamine hypothesis. Prog Brain Res.
The
dopamine hypothesis of drug addiction: Hypodopaminergic state.
Etiologic subtypes of attentiondeficit/ hyperactivity disorder: brain imaging, molecular genetic and environmental factors and the
dopamine hypothesis. Neuropsychol Rev 17(1):39-59.