Interestingly, our results showed that
ectopic expression of HtrA1 inhibited the mRNA expression of Notch-1 in PANC-1 cells (Figure 4A).
Up to now, several cell-targeting strategies have been developed to obtain the efficient mechanism for delivery of an interested gene to a particular target cell and operating its
ectopic expression in vitro.
This explains nicely why in a genome wide analysis of expression, genes are both repressed and activated when a transcription factor is either added (
ectopic expression) or taken away (loss of function).
As shown in Figures 3(c) and 3(d),
ectopic expression of GBP1 did not promote the migration of PDLSCs, but it further enhanced the migration activity of PDLSCs in presence of IFN-[gamma] at a concentration of 10 ng/ml.
Ectopic expression of a tomato 9-cis-epoxycarotenoid dioxygenase gene causes overproduction of abscisic acid.
The
ectopic expressions of Dab2 were observed in several human malignant cancer cell lines: Data pooled from eight studies in this meta-analysis showed that the
ectopic expression of Dab2 were observed in 17 human malignant cancer cell lines, including: A549, LTE, H1299, SH-SY5Y, HT1080, et al.
Conversely, LincRNA-EPS
ectopic expression by retroviral transduction was able to prevent apoptosis in erythroid cells starved for erythropoietin (Epo), an essential prosurvival and differentiating cytokine of the erythropoiesis system, even if it did not restore the terminal differentiation, as determined by the levels of haemoglobin.
Importantly, miR-30d
ectopic expression in an ATC cell line reduced monolayer cell growth and impaired anchorage-independent cell growth [30].