Pharmacology of
enkephalins inhibitors: animal and human studies.
It's not that
enkephalins or similar drugs make the rats like the chocolates more, the researchers say, but rather that the brain chemicals increase their desire and impulse to eat them.
Enkephalin is an endorphin with similar properties to opium.
In vitro effects of a synethetic
enkephalin analogue (D-Met2,Pro5)-enkephalinamide on the hypothalamus-pituitary--testis function in rats.
Activation of the pain control system increases the concentration of beta endorphin,
enkephalin, serotonin and norepinephrine levels in the brain tissue and plasma, thus creating an analgesic effect, as well as many others.
The Phase II study has been designed to evaluate NP2
Enkephalin for the treatment of severe and chronic cancer pain.
In other work by George and colleagues (1991), they concluded that a relative lack of
enkephalin peptides trans-synaptically, possibly resulting from enhanced
enkephalin degradation, might contribute to increased alcohol consumption in C57Bl/6J mice.
Ultrastructural localization of
enkephalin and u-opioid receptors in the rat ventral tegmental area.
Tears include a powerful hormone, leucine
enkephalin, which regulates pain and other hormones which regulate stress.
Effects of chronic lithium on
enkephalin systems and pain responsiveness.
"In addition to this newly acquired Endomorphin technology, and our exclusive licenses for GAD, we also have an ongoing clinical development program with
Enkephalin," saidsays Elisabeth Lindner, President and CEO of Diamyd Medical.