estradiol

[‚es·trə′dī‚ȯl]

(biochemistry)

C₁₈H₂₄O₂ An estrogenic hormone produced by follicle cells of the vertebrate ovary; provokes estrus and proliferation of the human endometrium, and stimulates ICSH (interstitial-cell-stimulating hormone) secretion.

The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Estradiol

C₁₈H₂₄O₂, a female sex hormone of the estrogen group with the structural formula

Estradiol occurs as colorless crystals with a melting point of 176°–178°C. Poorly soluble in water, it dissolves better in organic solvents. It is optically active, with a specific rotation of [α]_D= +81°.

Estradiol was first isolated in 1935 from the follicular fluid of the ovaries of swine by the American biochemist E. Doisy. Of all the estrogens, it has the highest physiological activity, but it is rapidly inactivated in the body. Longer-acting preparations of estradiol (estradiol dipropionate and estradiol benzoate) are obtained by the esterization of estradiol with various organic acids. Estradiol has important physiological functions (seeESTROGEN).

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References in periodicals archive

The investigators found also that, in contrast with CIMT, cardiac computed tomography (CT) measures of atherosclerosis did not differ significantly between the estradiol and placebo groups, regardless of age.

How does HT in recent and 10+ years past menopause affect atherosclerosis progression?

In a subgroup analysis of postmenopausal women with heart failure, investigators found a significant positive association with the testosterone to estradiol ratio (HR, 1.65; 95% CI, 1.07-2.54) and inverse associations for estradiol (HR, 0.60; 95% CI, 0.39-0.93) and for dehydroepiandrosterone (HR, 0.59; 95% CI, 0.44-0.78).

Testosterone in postmenopausal women may add CVD risk

At first, we found that female rats had few testosterone [Figure 4]a and male rat also showed low amount of estradiol [Figure 4]b as expected, and there were no difference among stressed animals, unstressed control and those in adaption no matter in testosterone [Figure 4]a or estradiol [Figure 4]b.

Estradiol level of male rat is correlated with depression and anxiety after traumatic stress

There appears to be a paucity of data in humans describing the role of estradiol and/or ER activation relative to the expression of genes targeted by ER signaling which are known to play a role in the myogenic activation of satellite cells.

Skeletal Muscle Estrogen Receptor Activation in Response to Eccentric Exercise Up-Regulates Myogenic-Related Gene Expression Independent of Differing Serum Estradiol Levels Occurring during the Human Menstrual Cycle

Concentrations of progesterone and estradiol in 25-50 [mu]l of plasma were determined in duplicate without extraction by using commercial RIA kits from DSL Laboratories Inc.

Interrelationships between reproductive cycle, age, body weight and steroid hormones in roe deer females (Capreolus capreolus)

The ex vivo resuscitated group, gives direct information about the cardioprotective effects of the treatment with estradiol outside the body, away from any endocrine, neural and other inflammatory pathways interference.

Protective Effects of Estradiol on Myocardial Contractile Function Following Hemorrhagic Shock and Resuscitation in Rats

stream by converting it into estradiol through aromatase in adipocytes.

ASSOCIATION OF BREAST CANCER WITH OBESITY AND ESTROGEN IN WOMEN

Progesterone (Sigma-Aldrich, Brazil) and estradiol benzoate (Sigma-Aldrich) were dissolved in an oil vehicle at concentrations of 0.5 and 0.05 mg/mL, respectively.

Behavioral effects of endogenous or exogenous estradiol and progesterone on cocaine sensitization in female rats

On the other hand, treatments with eCG can affect ovarian endocrine function and lead to an obvious increase in estradiol productions (Liu et al., 2007).

Influence of Different Doses of Equine Chorionic Gonadotropin on Follicular Population and Plasma Estradiol Concentration in Chinese Holstein Dairy Cows

Estradiol and BPS each increased cell proliferation, but following exposure to both compounds there were fewer cells than in control cultures.

Assessing the safety of a replacement chemical: nongenomic activity of bisphenol S