Till date, only a very limited number of studies have investigated the effect of transferring only
euploid embryos after PGS on pregnancy outcomes.
[20] had initially observed a deficit in such form of CA1 LTP in Ts65Dn mice compared with
euploid control mice, additional studies, beginning with Costa and Grybko [14], found that this form of LTP is unaffected in Ts65Dn mice.
y = [SIGMA][n.sub.(i, ..., j)] ([lambda] = 2) = 2 [n.sub.(i, ..., j)],
euploid, (1)
The DO ES lines have been shown to be
euploid and stable (T.
The main outcome measure of this study, which was performed by Dr Christos Venetis from the University of New South Wales and colleagues at IVF Australia, was the number of chromosomally normal ("
euploid") embryos identified by preimplantation genetic screening (PGS) in more than 700 treatment cycles at three IVF centres.
Penzias and fellow committee members reviewed national data from 2013 that showed similar pregnancy rates for women aged 42 years and younger who received a single
euploid blastocyst or two untested blastocysts.
PGS showed 10 aneuploid embryos and 1
euploid embryo.
The authors observed that, for each year increase in female age, euploidy rate decreased by 2.9 percentage points in both day 3 and blastocysts (95% CI: -3.8% to -2.0%, p < 0.001), and the odds of achieving at least one
euploid embryo were decreased as a function of increased female age in both groups (odds ratio (OR) 0.82, 95% CI 0.70-0.94, p = 0.006).
P19 cells have a male
euploid karyotype (40 and XY), and much like F9 cells are considered nullipotent [47].
Euploid embryos have a higher chance of implantation, and the resulting pregnancies have a lower chance of miscarriage.