Gametocytes were counted, based on the same mean WBC count of 6000/[micro]l .
Treatment of malaria patients with co-artemether reduces
gametocyte carriage and density in children and makes them less infectious to mosquitoes than treatment with sulfadoxine-pyrimethamine plus chloroquine (13).
Evidence shows that
gametocytes can persist for 1 year after infection (17).
The efficacy of the TBV will be dependent upon the proportion of
gametocyte carriers immunized in a local transmission area.
(15) This was the first identification of circulating
gametocytes in peripheral blood in a new host family and would have justified the establishment of a new species of hemoprotozoa.
This rapid clearance of
gametocytes is a major benefit of DHA/PPQ in comparison with chloroquine, given that P.
Targett, "Risk factors for
gametocyte carriage in Gambian children," The American Journal of Tropical Medicine and Hygiene, vol.
The rest of the daughter merozoites develop into sexual forms called
gametocytes [10].
Identifying factors associated to timely treatment can strengthen the strategies for malaria control program, especially considering the expected impact on
gametocyte availability for malaria vectors.
Phylogenetic Gene ID classification Trophozoite Schizont Merozoite PF3D7_0204700 Clade 2 + + + PF3D7_0919500 Clade 4 nd nd nd Blood stage Gene ID
Gametocyte I
Gametocyte II
Gametocyte III PF3D7_0204700 + + nd PF3D7_0919500 nd nd nd Mosquito/sexual stage Gene ID
Gametocyte IV
Gametocyte V Ookinete Sporozoite PF3D7_0204700 nd + nd + PF3D7_0919500 nd nd nd + Phylogenetic classification (see Figure 1); +: protein expression is detected; nd: not detected.