Glial cells throughout the body, especially in muscles that are starved of glucose (hypoglycaemia) will die, spilling out their carefully guarded reserves of glutamine and the enzyme
glutaminase --a deadly duo that becomes glutamate and joins up with calcium, its excitable partner.
Karsten Suhre, analyzed the metabolic processes of cancer cells to show that the quinine-based malaria drug Chloroquine could boost the effectiveness of
glutaminase inhibiting drugs, which are currently being developed by global pharmaceutical companies.
Role of phosphate-activated
glutaminase in the pathogenesis of hepatic encephalopathy.
Majority of children with type 1 diabetes produce and deposit anti-tissue trans
glutaminase antibodies in the small intestine.
-- Combination treatment with the first-in-class
glutaminase inhibitor CB-839 and nivolumab is well tolerated and shows clinical activity in patients with three types of cancer, including advanced melanoma, according to initial results of a phase 1/2 study
Glutamine is transferred back to neurons to be used as a substrate for the enzyme
glutaminase (GLS), which removes an amide group from glutamine to produce glutamate and ammonia [61] (Figure 2).
Screening and kinetics of
glutaminase and glutamate decarboxylase producing lactic acid bacteria from fermented Thai foods.
[23] Gln is converted to Glu by the
glutaminase in presynaptic neurons.
Glutamate and GABA-metabolizing enzymes in post-mortem cerebellum in Alzheimer's disease: Phosphate-activated
glutaminase and glutamic acid decarboxylase.