GNA NOW gives us the opportunity to join forces with leading institutions of both the public and the private sector across Europe to develop new
gram-negative antibacterial agents as quickly and as efficiently as possible.'
Present study was carried out to determine the frequency and antimicrobial susceptibility patterns of MBL producing carbapenem-resistant
Gram-negative rods (GNRs) from clinical isolates.
In a recent report on antimicrobial resistant pathogens, the World Health Organisation put several
gram-negative bacteria at the top of its list, stating that new treatments for these bacteria were 'Priority 1 Critical' because they cause infections with high death rates, are rapidly becoming resistant to all present treatments and are often picked up in hospitals.
* Chemical optimization of the arylomycins to obtain G0775, a molecule with potent, broad-spectrum activity against
Gram-negative bacteria
For the purpose of this study, we collected aerobic,
gram-negative rods (including enterobacteriaceae, pseudomonas (P.) aeruginosa, acinetobacter (A.) baumanii and burkholderia (B.) cepacia).
Phenotypic Detection of Carbapenem-Susceptible Metallo-[beta]-Lactamase-Producing
Gram-Negative Bacilli in the Clinical Laboratory.
Part of the problem has been that we don't really know what makes an antibiotic effective against
Gram-negative bacteria.
Of the 42 isolates, 34 (81%) were Enterobacteriaceae (20 Escherichia coli, 7 Klebsiella pneumoniae, 6 Salmonella enterica, and 1 Enterobacter cloacae) and 8 (19.0%) were nonfermenting
gram-negative bacilli.
The diabetic group showed no significant difference in frequency of bacterial growth compared to the control group, but yielded more
gram-negative bacterial cultures.
Published by Hans Christian Gram in 1884, gram staining distinguishes gram-positive bacteria (purple) from
gram-negative bacteria (pink).
The samples were analyzed for pH (acidity), total number of bacteria colonies present, number of gram-positive and
gram-negative colonies, and concentration of total protein, fat, fatty acids, lactoferrin, immunoglobulin A (IgA), and osmalality.
Teixobactin's one limitation is its inability to affect
gram-negative bacteria.