[36.] Madigan C, Malik P (2006) Pathophysiology and therapy for
haemoglobinopathies. Part I: sickle cell disease.
Testing for
haemoglobinopathies in Johannesburg, South Africa: A 30-year review.
In the light of the uncertainty in the influence of anaemia and
haemoglobinopathies on HbA1c, it is imperative that clinicians are aware of the caveats with HbA1c values when they make management decisions in the anaemic population.
Gorakshakar et al., "Prevalence of [beta]-thalassemia and other
haemoglobinopathies in six cities in India: a multicentre study," Journal of Community Genetics, vol.
However, EMH in the adrenal is uncommon,[sup.2] with less than 10 cases reported.[sup.3] It is thought to be a compensatory, physiological mechanism that occurs during altered medullary haematopoesis which is commonly seen in the
haemoglobinopathies, leukemias, lymphomas and myelofibrosis.
Rosatelli, "Prenatal diagnosis and screening of the
haemoglobinopathies," Baillieres Clinical Haematology, vol.
Spectrum of
haemoglobinopathies in the state of Orissa, India: A ten year cohort study.
His thesis was titled 'Molecular Genetics of
Haemoglobinopathies in Oman'.
Guideline: the laboratory diagnosis of
haemoglobinopathies. Br J Haematol 1998;101:783-92.
Jaundice in malaria infection is caused by many factors including intravascular haemolysis of parasitized red blood cells, haemolysis of non-parasitized red blood cells (innocent bystanders), possible micro-angiopathic haemolysis associated with disseminated intravascular coagulation (DIC), hepatic dysfunction, associated
haemoglobinopathies (not uncommon in malaria-prone areas), druginduced haemolysis (including quinine, etc.), G-6-PD deficiency, etc.
Deficiency or malfunction of these blood cells occurs in disease conditions prevalent in Africa, including cancers like leukaemia and
haemoglobinopathies like thalassaemia or sickle-cell disease.
Diagnosis of the
haemoglobinopathies. Clin Biochem Rev 2006; 27: 27-38.