The effect of trace
halothane exposure on triggering malignant hyperthermia in susceptible swine.
Subjects.--Twenty female HSD: Wistar rats (mean bodyweight 195 [+ or -] 16 g) were randomly assigned, five animals per group, to one of four groups; control (CON, no anesthesia), pentobarbital anesthetized (PEN), ketamine anesthetized (KWT), or
halothane anesthetized (HAL).
Thirty-three (63%) families had members who were susceptible to both
halothane and caffeine and were designated as MHS, whereas 37% of families had members who were susceptible to either
halothane or caffeine and were designated as MH equivocal (MHE).
For all radiographic and surgical procedures, the birds were given
Halothane as a general anesthetic.
Highly suspect drugs include acetaminophen,
halothane, methyldopa,
And his face was pressed into a jar of
halothane, a lethal gas used to kill laboratory rats.
However, volatile agents as well as other known trigger substances have been used in pediatric patients: uneventful inhalational induction and maintenance of anesthesia have been described with sevoflurane [2, 8] whereas
halothane has been linked to hyperpyrexia in several cases [5].
The event of mild hypotension (MAP=50 [+ or -] 6mmHg) in [MOR.sub.1.0] might be considered a limitation of this study because hypotension decreased
halothane MAC in dogs (TADIKONDA et al., 1981).
Carmichael, "Hemodynamic and organ bloodflow responses to
halothane and sevoflurane anesthesia during spontaneous ventilation," Anesthesia & Analgesia, vol.
Halothane was synthesised in 1951 and was introduced for clinical use in 1956.