A wide spectrum of ADRs affecting the gastrointestinal, CNS, cardiovascular, immune, and
hematopoietic system was reported.
of Cases Percentage Astrocytic Tumours 321 36.1% Oligodendroglial Tumours 40 4.5% Ependymal Tumours 42 4.7% Choroid Plexus Tumours 2 0.2% Neuronal and Mixed 16 1.8% Neuronal-Glial Tumours Tumours of Pineal Region 2 0.2% Embryonal Tumours 37 4.3% Tumours of Cranial and 103 11.6% Paraspinal Nerves Meningeal Tumours 213 23.9% Tumours of
Hematopoietic System 9 1% Germ Cell Tumours 2 0.2% Tumours of Sellar Region 21 2.3% Metastatic Tumours 82 9.2% Table 2.
Expression of the G-CSFR is predominantly in cells of the
hematopoietic system with the highest expression in neutrophils [48, 49].
2011), it remains critical to identify the long-term cellular and molecular targets in the
hematopoietic system. In experimental systems, the AHR has been identified as a negative regulator of hematopoietic stem cell proliferation (Singh et al.
Based on the therapeutic applications the global API market is categorized into eleven crucial application areas such as anti-infectives, oncology, cardiovascular and
hematopoietic system, central nervous system, gastrointestinal disorder, respiratory system, hormonal-related disorder, metabolic disorder, genito-urinary disorder, musculo-skeletal disorder and others.
However, cancer chemotherapy regimens have adverse effects on the
hematopoietic system. Neutropenia is a disorder in which a patient has a low absolute neutrophil count in comparison to a healthy individual.
They address three-dimensional expansion methods for producing therapeutic cell products derived from placental or fat cells and the use of placenta-derived cells grown with this 3D technology to treat disorders of the
hematopoietic system, such as disorders caused by exposure to radiation or chemotherapy, and failed engraftment of hematopoietic stem cell transplants.
They address three-dimensional expansion methods for producing therapeutic cell products derived from placental or fat cells and the use of placenta -derived cells grown with this 3D technology to treat disorders of the
hematopoietic system, such as disorders caused by exposure to radiation or chemotherapy, and failed engraftment of hematopoietic stem cell transplants.
PNH is a rare acquired disorder of the
hematopoietic system, characterized by increased susceptibility of red blood cells to complement mediated cell lysis, due to absence of glycophosphatidylinositol linked proteins.
Acute erythroid leukemia is a form of neoplasia of the
hematopoietic system in which there is involvement of immature cells of the erythroid lineage (VALLI et al., 8000; FIGHERA & GRACA, 8010).
They cover the gastrointestinal system; the liver; the kidney; soft tissue; bone; central nervous system and skeletal muscles; the
hematopoietic system; the heart; the lung; pancreas, adrenal, thyroid, parathyroid, and selected head and neck; breast and reproductive system; and skin.