Encyclopedia

Homozygote

Also found in: Dictionary, Medical, Wikipedia.

homozygote

[¦hō·mə′zī‚gōt]
(genetics)
An individual who has identical alleles at one or more loci and therefore produces identical gametes with respect to these loci.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Homozygote

 

a cell or an organism in whose genetic makeup the homologous chromosomes carry the identical form of a given gene. A homozygote originates during the fusion of gametes that are identical for a given gene. The genetic formula of a diploid organism homozygous for allele A or a can be written in the form AA or aa; for a triploid organism, AAA or aaa; and so forth.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
Mentioned in
References in periodicals archive
Hence, in wild-type alleles (135 GG), the amplified fragment was digested using Mval (Thermo Scientific, Waltham, MA, USA) producing 86 and 71 bp products, whereas in 135 CC homozygotes, it was not digested resulting in a single 157 bp product.
Positive effect of single nucleotide RAD51 135G>C polymorphism and low Ku70 protein expression on female rectal cancer patients survival after preoperative radiotherapy
In the present study, individuals harboring mutant homozygote AA showed a more effective response to fentanyl than those with GG or GA.
Impact of CYP3A4*1G Polymorphism on Fentanyl Analgesia Assessed by Analgesia Nociception Index in Chinese Patients Undergoing Hysteroscopy
In agreement with our results, Qi et al, (15) identified TT homozygote genotype of ABCA1 C-565T polymorphism as a significant risk factor for CAD development.
The C-565T Polymorphism (rs2422493) of the ATP-binding Cassette Transporter A1 Gene Contributes to the Development and Severity of Coronary Artery Disease in an Iranian Population
A significant increased risk in the homozygote model (GG versus AA: OR= 1.72, 95% CI 1.19-1.49, [P.sub.H] = 0.24) was observed, while no significant association was found in other models (G versus A: OR= 1.08, 95% CI 0.92-1.28, [P.sub.H] = 0.38; GA versus AA: OR = 0.62, 95% CI 0.29-1.35, [P.sub.H] < 0.001; GG + GA versus AA: OR = 0.81, 95% CI 0.66-1.00, [P.sub.H] = 0.17; and GG versus GA + AA: OR= 1.74, 95% CI 0.68-4.49, [P.sub.H] = 0.016).
Association of Three Polymorphisms rs11614913, rs2910146, and rs3746444 in miRNA-196a2, miRNA-146a, and miRNA-499 with Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis
Frequency Genotype (percent) Heterozygote 17(40) E148Q 7(16) M694V 5(12) M680I(G>C) 2(5) P369S 1(2) V726A 1(2) M694I 1(2) Compound heterozygote 16(37) M694V/R761H 4(9) M694I/R761H 2(5) M680I/E148Q 2(5) M680I/M694V 3(7) P369S/E148Q 1(2) E148Q/M694I 1(2) M694V/V726A 1(2) M680I/R761H 1(2) V726A/R761H 1(2) Homozygote 9(21) M694V/M694V 4(9) M680I/M680I 3(7) V726A/V726A 2(5) Complex alleles mutations P369S/ E148Q/ E148Q 1(2) Table 2: Frequency of mutations in Familial Mediterranean Fever patients and parents.
Familial Mediterranean Gene (MEFV) Mutation in Parents of Children with Familial Mediterranean Fever: What Are the Exceptions?
In terms of INR levels of the patient group, no statistical difference was found between VKORC 1 and CYP2C9 haplotypes (p=0.305 and p=0.088, respectively), whereas a significant difference was found on weekly warfarin dosages of VKORC 1 homozygote normal GG and CYP2C9 *1/*1 homozygote normal (wild) carriers (p=0.02 and p=0.034, respectively) (Table 4).
Evaluation of the VKORC 1 and CYP2C9 Gene Polymorphisms and Their Effects on the Emergency Complications in the Patients Using Warfarin
The aim of the current study is to isolate homozygous [alpha]GT KO cells from postnatal heterozygous [alpha]GT KO skin fibroblasts and ultimately to evaluate the developmental competence of isolated homozygote cells after SCNT.
Alpha-1, 3-galactosyltransferase-deficient miniature pigs produced by serial cloning using neonatal skin fibroblasts with loss of heterozygosity
Our selected group c.35delG genotype N (%) (familial cases) Homozygote WT* 109 (82.6%) Only the deaf Heterozygote 35delG 2 (1.5%) Homozygote 35delG 21 (15.9%) Total 132 Homozygote WT* 291 (86.3%) All subjects Heterozygote 35delG 25 (74%) Homozygote 35delG 21 (6.2%) Total 337 *WT: wild type.
Frequency of c.35delG Mutation in GJB2 Gene (Connexin 26) in Syrian Patients with Nonsyndromic Hearing Impairment
Each dot point represents a different homozygote. Homozygous haplotypes for MPRIP-TCAP region only.
Haplotypes for Type, Degree, and Rate of Marbling in Cattle Are Syntenic with Human Muscular Dystrophy
We conclude that the population of Hemiodus orthonops dwelling the upper Parana River basin is genetically structured and they show homozygote excess probably due to founder effect.
Genetic variability and evidence of founder effect in Hemiodus orthonops (Characiformes: Hemiodontidae) from the upper Parana River basin, Brazil/Variabilidade genetica e evidencia do efeito do fundador em Hemiodus orthonops (Characiformes: Hemiodontidae) da bacia do alto rio Parana, Brasil
Copyright © 2003-2025 Farlex, Inc Disclaimer
All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional.