Chertov et al., "A protease-resistant
immunotoxin against CD22 with greatly increased activity against CLL and diminished animal toxicity," Blood, vol.
Major cancer regressions in mesothelioma after treatment with an anti-mesothelin
immunotoxin and immune suppression.
In the present study, we reported the novel
immunotoxin PT by fusing the scFv of Pan to 38 kDa truncated fragment of PE and investigated its potent antitumor potency against esophageal cancer cells in vitro and in vivo.
[sup][14] first reported a novel
immunotoxin that could kill cancer cells.
In order to determine whether all damages to ipRGCs were caused by the injection of
immunotoxin, or whether theses damages were also potentially related with age, we immunohistochemically labeled ipRGCs using antibodies against melanopsin and compared the number of ipRGCs on flat-mounted retina among 1-, 3-, and 6-month-old rd mice (n = 6 in each age group) (the detailed methodology is described below).
(2000) Site-specific chemical modification with polyethylene glycol of recombinant
immunotoxin anti-Tac(Fv)-PE38 (LMB-2) improves antitumor activity and reduces animal toxicity and immunogenicity.
Cytotoxic activity of the recombinant anti-mesothelin
immunotoxin, SS1(dsFv)PE38, towards tumor cell lines established from ascites of patients with peritoneal mesotheliomas.
Half of the animals subsequently received a two-week dose of a genetically designed, HIV-specific poison, or
immunotoxin, to complement the antiretrovirals, while the other half continued receiving antiretrovirals alone.