kanamycin

[‚kan·ə′mīs·ən]

(microbiology)

C₁₈H₃₆O₁₁N₄ A water-soluble, basic antibiotic produced by strains of Streptomyces kanamyceticus; the sulfate salt is effective in infections caused by gram-negative bacteria.

The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Kanamycin

(Kantrex, Resistomycin), an antibiotic of the amino glycoside group.

Kanamycin was first obtained from the actinomycete Strep-tomyces kanamyceticus in 1957. It is soluble in water, thermostable, and polybasic. Kanamycin is effective against most gram-negative and gram-positive bacteria and mycobacteria. It is ineffective against yeasts, fungi, enterococci, and bacteroids. Kanamycin sulfate solution is administered intramuscularly in the treatment of tuberculosis. Although kanamycin has a low level of toxicity, in large doses it produces side effects on the kidneys and acoustic nerves.

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References in periodicals archive

Bean regenerants with kanamycin were selected during three to five weeks for stable transformation.

Transformacion de frijol comun (Phaseolus vulgaris) var. Brunca mediada por Agrobacterium tumefaciens

Overexpression of the chromosomally encoded aminoglycoside acetyltransferase eis confers kanamycin resistance in Mycobacterium tuberculosis.

Cross-Border Movement of Highly Drug-Resistant Mycobacterium tuberculosis from Papua New Guinea to Australia through Torres Strait Protected Zone, 2010-2015

pneumoniae isolates to gentamicin, kanamycin, tobramycin, and amikacin was 34.6, 43.8, 33.8, and 14.6%, respectively.

Evaluating the Frequency of aac(6')-lla, ant(2")-l, intll, and intl2 Genes in Aminoglycosides Resistant Klebsiella pneumoniae Isolates Obtained from Hospitalized Patients in Vazd, Iran

tumefaciens strain GV3101 harboring pCAMBIA-1301-CsEXP10 was grown on Yeast Extract Peptone (YEP) medium supplemented with 50 mg L-1 kanamycin and 50 mg L-1 rifampicin on incubator shaker (28 +-1degC, 250 rpm) for 16 h.

Establishment of a High-efficiency Genetic Transformation System of Cucumber (Cucumis sativus) using Csexpansin 10 (CsEXP10) Gene

amylovora were grown on NGA with added kanamycin (Km) at 28degC.

THE ROLE OF DSPF, THE TYPE III SECRETION CHAPERONE OF DSPA/E OF ERWINIA AMYLOVORA, IN PATHOGENICITY IN HOST AND NON-HOST PLANTS

The next most frequent resistance isolates were resistance to erythromycin, cefoxitin, clindamycin, ampicillin, amoxicillin, tetracycline, and kanamycin 2 (8.33%).

Cloacael Carriage and Multidrug Resistance Escherichia coli O157:H7 from Poultry Farms, Eastern Ethiopia

was found to be maximum sensitive (Table 3) for Ciprofloxacin (100%) followed by Norfloxacin (85.71%), Tobramycin (85.71%), Ceftriaxone (71.42%), Amikacin (71.42%), Amoxycillin (71.42%), Ampicillin (71.42%) and Enrofloxacin (57.14%) but less sensitive to Neomycin, Streptomycin, Chloramphenicol, Kanamycin, Cefoperazone and Cephalexin.

Bacterial Isolates and their Antibiograms from Diarrhoeic Buffaloes

LaPiana, "Pharmacokinetics of kanamycin following intramuscular administration," Journal of Pharmacokinetics and Biopharmaceutics, vol.

Kanamycin Sulphate Loaded PLGA-Vitamin-E-TPGS Long Circulating Nanoparticles Using Combined Coating of PEG and Water-Soluble Chitosan

Future studies should use antimicrobial agents such as cephalosporins, fluoroquinolones, and trimethoprim, which are now more commonly in use over some of the redundant (oxytetracycline, chlortetracycline, and tetracycline) antimicrobials or ones that are no longer commonly used to treat clinical infections (kanamycin, chloramphenicol, and nalidixic acid) to better determine the pollution source.

Using multiple antibiotic resistance profiles of coliforms as a tool to investigate combined sewer overflow contamination

As compared to standard antifungal disc kanamycin, these complexes showed minor activity against selected fungal strains at 50 u l.

Synthesis and Antifungal Studies of Copper Complexes with Glutamine and Cysteine