The top three most common causes of CP in this study were birth asphyxia, CNS infections and
kernicterus. This finding is in agreement with previous studies in Nigeria.
Definition of the clinical spectrum of
kernicterus and bilirubin induced neurologic dysfunction (BIND).
Mr Jones added that the case was one of a number of claims from across the country being handled by his firm for similar mistakes resulting in
kernicterus affecting other children.
Mollison and Cutbush noticed a close relationship between peak serum bilirubin concentration and development of
kernicterus. [21] In mature infants,
kernicterus seldom developed when serum bilirubin concentrations were less than 18 mg/dL.
There is currently a gap in point of care testing devices for G6PD, a deficiency that leads to hyperbilirubinemia and approximately 21% of
kernicterus cases.
Trendsin hospitalizations for neonatal jaundice and
kernicterus in the United States, 1988-2005.
The association between hyperbilirubinemia and encephalopathy was first described in 1847 by Hervieux; the term
kernicterus was first used by Schmorl in 1903 to describe yellow staining of the basal ganglia [1].
[12] on socioclinical issues in CP in Sagamu, Nigeria, revealed that, of 92 patients attending the pediatric neurology clinic at Olabisi, Onabanjo University Teaching Hospital, Sagamu, Nigeria, between the periods of 2000 and 2006, birth asphyxia was associated with 57.6% cases, being the leading cause,
kernicterus, 36.9%, and central nervous system infection, 21.7%.
PARENTS OF INFANTS AND CHILDREN WITH
KERNICTERUS (PICK)
Settlements, which depend on both adverse outcomes and their causality, such as the death of an adult from a missed critical cardiac biomarker result in the clinical laboratory or at the point of care, or the lifelong disastrous mental impairment of an infant from
kernicterus following an overlooked elevated bilirubin level not treated promptly with phototherapy, can be in the range of millions of dollars.
In the final stage of pregnancy, use of the sulfamethoxazole/trimethoprim combination should be avoided due to the risk of neonatal
kernicterus. As current treatment options, use of intravitreal klindamycin (1.0 mg/0.1 ml) and dexamethasone (400 [micro]g/0.1 ml) injections to avoid systemic toxicity has been reported.