Our laboratory has developed long-term models of both low and high lead nephropathy in male Sprague-Dawley rats fed a low calcium diet (123-125).
Thus these studies join those in humans (81,197,126) which indicate that lead nephropathy should be added to diabetic nephropathy as diseases which may lead to hyperfiltration early in the course.
Acute lead intoxication without renal involvement or lead nephropathy ordinarily is treated with EDTA chelation.
Beta2-microglobulinuria is not found in lead nephropathy, while NAG and GST, indicative of tubular injury, are seen in both cadmium nephropathy and lead nephropathy.
Calcium versenate in the diagnosis of chronic lead nephropathy. Med J Aust 1960; 47 : 243-8.
Hyperkalemia and acidosis in lead nephropathy. South Med J 1976; 69: 881-3,6.
The relative contribution of tubular reabsorption and secretion to urate excretion in lead nephropathy. Aust N Z J Med 1971 ; I : 353-62.