Release date- 30082019 - NEW YORK - Akari Therapeutics, Plc (Nasdaq: AKTX), a biopharmaceutical company focused on innovative therapeutics to treat orphan autoimmune and inflammatory diseases where the complement (C5) and/or
leukotriene (LTB4) systems are implicated, today announced that the U.S.
Cysteinyl
leukotrienes in asthma: old mediators up to new tricks.
Leukotrienes are lipid mediators involved in allergic and inflammatory diseases (8).
Senior investigator and director of Alzheimer's Center at Temple University, Domenico Pratico, explained: "At the onset of dementia,
leukotrienes attempt to protect nerve cells, but over the long term, they cause damage.
"
Leukotrienes are in the lungs and the brain, but we now know that in addition to their functional role in asthma, they also have a functional role in dementia," Dr.
Glucocorticoids reduce the prostaglandin,
leukotriene synthesis that are released from activation of phospholipaseA2 which reduced the expression of cyclooxygenase-2 in inflammatory cells.5
The arachidonic acid cascade plays an important role in skin inflammation because it activates cyclooxygenase-2 (COX-2), which leads to the synthesis of substances such as prostaglandins and
leukotrienes. These compounds cause inflammation and recruit inflammatory immune cells to the area.
OX-CLI is a
Leukotriene (LT) C4 Synthase inhibitor program directed to develop a novel treatment of respiratory disorders such as asthma and COPD.
From the time when the concept of inflammation and atherosclerosis was raised, a number of inflammatory mediators have been explored as potential therapeutic targets in this disease [68] and, among these,
leukotrienes also have been investigated [35].
Transcellular biosynthesis of cysteinyl
leukotrienes in rat neuronal and glial cells.
Taken orally, zileuton inhibits the 5-LO enzyme, which would otherwise catalyze the formation of
leukotrienes from arachidonic acid.