Only a few studies have reported alterations in urine levels of
matrix metalloproteinases and tissue inhibitor of metalloproteinases in patients with type 1 diabetes mellitus and these studies have conflicting results.
Matrix metalloproteinases (MMPs) are special class of proteases that are categorized in five groups as per their substrate specificity: collagenases (MMP-1, -8 and -13), gelatinases (MMP-2 and -9), stromelysins (MMP-3, -10, and -11), matrilysins (MMP-7) and membrane-type (MMP-14 to -17, -24 and -25).
[1.] Nagase H, Visse R, Murphy G (2006) Structure and function of
matrix metalloproteinases and TIMPs.
Matrix metalloproteinases (MMPs), extracellular-degrading proteases, contribute to metastatic and invasive cancer cells properties; their expression (particularly MMP-9 and MMP-2) is increased in carcinomas (Stamenkovic, 2000) MMPs activity can be specically inhibited by a group of structurally related, endogenous inhibitors known as tissue inhibitors of metalloproteases (TIMPs) (Al-Olayan et al., 2014).
Presence of
matrix metalloproteinases and tissue inhibitor of
matrix metalloproteinase in human sperm.
The
matrix metalloproteinases (MMPs) play an important role in the process of cardiac remodeling by regulating structural integrity of the extracellular matrix.[9] MMP-2 is one of the predominant MMPs expressed in the cardiac ventricles.
Biochemical evidence indicates that serum proteinases, namely,
matrix metalloproteinases (MMPs), play key roles in the pathophysiology of this malignancy.
Hughes et al., "Aggrecanase versus
matrix metalloproteinases in the catabolism of the interglobular domain of aggrecan in vitro," Biochemical Journal, vol.
The diagnostic value of
matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of
matrix metalloproteinases 1 (TIMP-1) determination in the sera of colorectal adenoma and cancer patients.
Benhamou, "
Matrix metalloproteinases and diabetic foot ulcers: the ratio of MMP-1 to TIMP-1 is a predictor of wound healing," Diabetic Medicine, vol.