It is reported that vitamin D has antiapoptotic effects and can increase
melanogenesis and tyrosinase content (4, 22).
Zinc is an antioxidant that aids wound healing, protects against free radicals, supports
melanogenesis, and possibly prevents melanocyte death, but can cause gastrointestinal irritation.
Active ingredients with antioxidant and anti-tyrosinase abilities can exert skin protection and inhibit
melanogenesis (35).
Jung et al., "The mixture of different parts of Nelumbo nucifera and two bioactive components inhibited tyrosinase activity and
melanogenesis," Journal of Cosmetic Science, vol.
The morphology, histochemical properties, and ultrastructure of the pigmented cells may indicate that the
melanogenesis takes place in these cells, and then, the melanin is transferred to pinealocytes and interstitial cells.
Sjoquist, "Age-related
melanogenesis in the eye of mice, studied by microautoradiography of 3H-methimazole, a specific marker of melanin synthesis," Experimental Eye Research, vol.
Xu et al., "Inhibitory effects of (2'R)2',3'-dihydro-2'-(1-hydroxy-1-methylethyl)- 2,6'-bibenzo- furan-6,4'-diol on mushroom tyrosinase and
melanogenesis in B16-F10 melanoma cells," Phytotherapy Research, vol.
The cosmetics industry is interested in plant natural tyrosinase inhibitors for potential use as inhibitors of
melanogenesis. This study investigated the kinetics of tyrosinase inhibition by a proso millet extract.
The KIT-ligand (steel factor) and its receptor c-KIT/W: pleiotropic roles in gametogenesis and
melanogenesis. Dev.
Reasons for its skin lightening effect include: its antioxidant properties, ability to switch eumelanin to pheomelanin which is the type of melanin found in lighter skin-toned individuals and the inhibitory effect it has on tyrosinase which is a key enzyme in
melanogenesis.2