Mononuclear phagocytes represent a cell lineage consisting of
monoblasts, promonocytes, monocytes, and macrophages.
The bone marrow was replaced by 90%
monoblasts. Flow cytometry was conducted on the leukemic cells.
LC can be defined as myeloid sarcoma or granulocytic sarcoma, in which the infiltrate is characterized by neoplastic granulocytic precursors; otherwise, when the infiltrate is composed of neoplastic monocytic precursors (
monoblasts and promonocytes), LC can be labeled monoblastic sarcoma (1).
Pluripotential stem cell Myeloid Progenitors Myeloblast
Monoblasts Marrow pool Mitotic Promelocytes Promonocytes precursors Myelocytes Post-mitotic Metamyelocytes bands Blood and Neutrophils, Monocytes tissue eosinophils and function basophils Innate Macrophage immunologic function Progenitors Megakaryocyte Erythroid Lymphoid Marrow pool Mitotic Maturing Normoblasts Pre-B precursors megakaryocytes Post-mitotic Reticulocytes B lymphoblast Blood and Platelets Erythrocytes B tissue lymphocytes function and plasma cells Haemostasis Oxygen Adaptive transport immunologic function Progenitors Marrow pool Mitotic Pro-T precursors Post-mitotic Lymphoblast Blood and T-lymphocytes tissue and NK cells function Fig.