Chronic idiopathic myelofibrosis is a myeloproliferative disorder characterized by splenomegaly,
myeloid metaplasia and reactive bone marrow fibrosis.
Long term analysis of the palliative benefit of 2-chlorodeoxyadenosine for myelofibrosis with
myeloid metaplasia. Eur J Haematol.
Among the 7 cases only one showed features of
myeloid metaplasia with extensive areas of calcification with an old hematoma.
Evaluation and clinical correlations of bone marrow angiogenesis in myelofibrosis with
myeloid metaplasia. Blood 2000;96:3374-80.
(2006) MPLW515L is a novel somatic activating mutation in myelofibrosis with
myeloid metaplasia. PLoS Med.
GlobalData's clinical trial report, "
Myeloid Metaplasia Global Clinical Trials Review, H2, 2015" provides an overview of
Myeloid Metaplasia clinical trials scenario.
Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and
myeloid metaplasia with myelofibrosis.
MF is characterized by clonal hematopoiesis, bone marrow stromal changes, and
myeloid metaplasia, which cause debilitating symptoms, hepatosplenomegaly, ineffective hematopoiesis, and increased risk of morbidity and mortality because of bone marrow failure, thrombotic/hemorrhagic events, and transformation to acute leukemia (1).