Systems for transforming matter, energy, and information, based on nanometer-scale components with precisely defined molecular features. The term nan-otechnology has also been used more broadly to refer to techniques that produce or measure features less than 100 nanometers in size; this meaning embraces advanced microfabrication and metrology. Although complex systems with precise molecular features cannot be made with existing techniques, they can be designed and analyzed. Studies of nanotechnology in this sense remain theoretical, but are intended to guide the development of practical technological systems.
Nanotechnology based on molecular manufacturing requires a combination of familiar chemical and mechanical principles in unfamiliar applications. Molecular manufacturing can exploit mechanosynthesis, that is, using mechanical devices to guide the motions of reactive molecules. By applying the conventional mechanical principle of grasping and positioning to conventional chemical reactions, mechanosynthesis can provide an unconventional ability to cause molecular changes to occur at precise locations in a precise sequence. Reliable positioning is required in order for mechanosynthetic processes to construct objects with millions to billions of precisely arranged atoms.
Mechanosynthetic systems are intended to perform several basic functions. Their first task is to acquire raw materials from an externally provided source, typically a liquid solution containing a variety of useful molecular species. The second task is to process these raw materials through steps that separate molecules of different kinds, bind them reliably to specific sites, and then (often) transform them into highly active chemical species, such as radicals, carbenes, and strained alkenes and alkynes. Finally, mechanical devices can apply these bound, active species to a workpiece in a controlled position and orientation and can deposite or remove a precise number of atoms of specific kinds at specific locations.
Several technologies converge with nanotechnologies, the most important being miniaturization of semiconductor structures, driven by progress in microelectronics. More directly relevant are efforts to extend chemical synthesis to the construction of larger and more complex molecular objects. Protein engineering and supramolecular chemistry are active fields that exploit weak intermolecular forces to organize small parts into larger structures. Scanning probe microscopes are used to move individual atoms and molecules.
| Fixing One Cell at a Time |
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| By 2020, scientists at Rutgers University believe that nano-sized robots will be injected into the bloodstream and administer a drug directly to an infected cell. This robot has a carbon nanotube body, a biomolecular motor that propels it and peptide limbs to orient itself. Because it is composed of biological elements such as DNA and proteins, it will be easily removed from the body. (Image courtesy of the Bio-Nano Robotics team at Rutgers University: Constantinos Mavroidis, Martin L. Yarmush, Atul Dubey, Angela Thornton, Kevin Nikitczuk, Silvina Tomassone, Fotios Papadimitrakopoulos and Bernie Yurke.) |