(9-16) In mice, Reishi has been found to promote the maturation and activation of immune system cells such as T cells,
natural killer cells, dendritic cells, and macrophages.
Ribeiro et al., "NKAML: a pilot study to determine the safety and feasibility of haploidentical
natural killer cell transplantation in childhood acute myeloid leukemia," Journal of Clinical Oncology, vol.
Porto et al., "Age-related changes in
natural killer cell receptors from childhood through old age," Human Immunology, vol.
Ben-Eliyahu, "The effects of sex, menstrual cycle, and oral contraceptives on the number and activity of
natural killer cells," Gynecologic Oncology, vol.
Suzuki et al., "Genome-wide array-based comparative genomic hybridization of
natural killer cell lymphoma/leukemia: different genomic alteration patterns of aggressive NK-cell leukemia and extranodal NK/T-cell lymphoma, nasal type," Genes Chromosomes and Cancer, vol.
A human
natural killer cell subset provides an innate source of IL-22 for mucosal immunity.
Medvik et al., "Baseline levels of soluble CD14 and CD16+56-
natural killer cells are negatively associated with response to interferon/ribavirin therapy during HCV-HIV-1 coinfection," Journal of Infectious Diseases, vol.
A novel method for the simultaneous assessment of
natural killer cell conjugate formation and cytotoxicity at the single-cell level by multi-parameter flow cytometry.
Role of
natural killer cell function in dendritic cell-based vaccines.
The investigators assessed 57 women over 2 years and found that variations in
natural killer cell levels corresponded to changes in depression status and ratings on the 17-item Hamilton Depression Rating Scale.
No significant changes were observed in the verum period for the following types of cells: T- and B-lymphocytes, CD4+- and CD8+-T-lymphocytes including the subgroups of "naive" and "memory" CD4+- and CD8+-T-lymphocytes as well as the
natural killer cells. Using a modified version of the Wilcoxon-Mann-Whitney-U-test, which is claimed to be optimal for the evaluation of the results of studies with a cross-over design, a significant difference was found for the number of CD8+-T-lymphocytes and
natural killer cells corresponding to either a decrease during treatment with verum or an increase in the number of these cells in the placebo period.