necrobiosis

[¦ne·krō‚bī′ō·səs]

(medicine)

Death of a cell or group of cells under either normal or pathologic conditions.

The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Necrobiosis

the change that occurs in a cell prior to cell death. Necrobiosis is linked with metabolic disturbances that may lead to fatty degeneration or to other types of degeneration in the cell. These degenerative changes can be reversible. The most typical symptoms of necrobiosis are changes in the cell nucleus, such as karyopyknosis, karyorrhexis, and karyolysis; disturbances in the viscosity of the cytoplasm; an abnormal staining reaction; and disorganization of the enzyme systems of the cell, which leads to cellular autolysis.

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References in periodicals archive

Some of the cutaneous markers of diabetes mellitus like necrobiosis lipoidica diabeticorum, diabetic bullae, acquired perforating dermatosis and stiff skin syndrome is not seen in our study.

A descriptive study-cutaneous manifestations of diabetes

Squamous cell carcinoma arising in an area of long-standing necrobiosis lipoidica. J Cutan Pathol.

Unsightly rash on shin: what started as a few small red spots was now an 8 x 6 cm well-demarcated red-brown plaque on the patient's shin. Was it linked to her diabetes?

Biopharmaceutical company Processa Pharmaceuticals Inc (OTC:PCSA) disclosed on Friday the receipt of US Food and Drug Administration (FDA) orphan-drug designation for its leading clinical compound PCS499 for treatment of Necrobiosis Lipoidica (NL).

Processa wins US FDA orphan designation status for PCS499 for Necrobiosis Lipoidica (NL)

M2 PHARMA-June 25, 2018-Processa wins US FDA orphan designation status for PCS499 for Necrobiosis Lipoidica (NL)

Processa wins US FDA orphan designation status for PCS499 for Necrobiosis Lipoidica (NL)

For ulcerative lesions of PG, frequent differential diagnosis include infective such as necrotizing fascitis, vascular occlusive or venous disease, necrobiosis lipoidica, livedoid vasculitis, sarcoidosis, or cutaneous malignancies such as squamous cell carcinoma and basal cell carcinoma, vasculitic processes such as Wegener's, malignancy such as lymphoma or leukemia, and pustular drug reactions.

Pyoderma gangrenosum at caesarean incision site response to dexamethasone therapy

Localized granuloma annulare must be differentiated from the most common annular lesion, tinea corporis, as well as other annular lesions, including necrobiosis lipoidica and erythema migrans.

Confluent annular lesion on the dorsum of the hand

The absence of diabetic thick skin and necrobiosis lipoidica diabeticorum (NLD) in the present study when compared to other studies,2,8,23 (Table 5) is mainly due to short duration of DM in the majority of the patients.

Spectrum of cutaneous manifestations in diabetes mellitus and their association with duration of diabetes mellitus: An observational study in a tertiary care hospital of South India

Topical tacrolimus in granuloma annulare and necrobiosis lipoidica. Br J Dermatol.

Granuloma annulare mimicking sarcoidosis and treated with acitretin: a case report

Necrobiosis lipoidica (NL) is another necrobiotic disorder with lesions occurring mainly over legs but can involve other sites as well and is seen in 0.3-1.6% of diabetic patients.9 In this study, necrobiosis lipoidica was seen in 1 (0.3%) case.

Pattern of dermatological diseases in patients of diabetes mellitus