Foci of myxoid degeneration, inflammation, and occasional multinucleated cells were found, concordant with the histologic pattern of
nodular fasciitis. The tumor margins could not be evaluated due to the fragmentized nature of the specimen.
TFL-like lesions should be differentiated from more commonly encountered lesions of the head and neck like fibromatoses,
nodular fasciitis, malignant fibrous histiocytomas, and fibrosarcomas.
Nodular fasciitis, a rapidly growing lesion, arises from superficial fascia and comprises fibroblasts and myofibroblasts in a myxoid stroma with prominent vasculature.
Nodular fasciitis of the external ear region: a clinicopathologic study of 50 cases.
The cellularity is usually low but can be variable and is often higher at the edge, sometimes resembling
nodular fasciitis. There are characteristic elongated (slit-like) thin-walled vessels or clefts.
Moreover, in cases of inadequate removal with the remnant of the tumor at the resection margins, it may recur, for differential diagnosis of a granular cell tumor in the subcutaneous tissue and muscle, candidates includes malignant fibrous histiocytoma, alveolar soft part sarcoma, desmoid, granulomatous and
nodular fasciitis.
We describe a case of
nodular fasciitis of the submental area, and we discus the clinical presentation and cytologic, histologic, and radiologic features of this uncommon condition.
The differential diagnosis of intradermal
nodular fasciitis includes FH and spindle cell sarcomas.
The histopathological picture was in keeping with a diagnosis of
nodular fasciitis.
The differential diagnosis includes myositis ossificans, proliferative myositis,
nodular fasciitis, and sarcoma.
Other differential diagnoses in terms of the histopathologic features of MCB include myoepithelial carcinoma of the breast, myofibroblastic tumors, phyllodes tumors, primary breast sarcoma,
nodular fasciitis, fibromatosis, pleomorphic adenoma, and adenomyoepithelioma.
The other differential diagnosis include
Nodular fasciitis and Fibromatosis of which the former shows microcystic change, abundant mitosis and lacks prominent inflammatory infiltrate whereas the latter shows fascicles of long sweeping fibroblastic cells with patchy chronic inflammatory cell infiltration.