Keywords: Cinchonidine, cinchonine, quinine,
noscapine, lipoxygenase, xanthine oxidase.
Singh, "Anticancer activity of
Noscapine, an opioid alkaloid in combination with Cisplatin in human non-small cell lung cancer," Lung Cancer, vol.
Scientists have long known how the plants make opiates such as codeine and morphine, but the molecular steps the plants use to make a non-addictive substance called
noscapine have been a mystery until now.
In the late 1980s when the reaction occurred, papaveretum contained 47.5 to 52.5% morphine, 2.5 to 5.0% codeine, 16.0 to 20.0% narcotine (
noscapine) and 2.5 to 7.0% papaverine (104).
The five major alkaloids are mainly divided into two distinct chemical classes (Reisine 1996:527)--phenanthrenes (morphine, codeine thebaine) and benzylisoquinolines (papaverine and
noscapine).
We also use pharmaceutical agents with known anticancer activity, including COX-2 inhibitors such as Celebrex, Metformin,
Noscapine, Disulfram, LDN (low-dose naltrexone), sodium phenylbutyrate, tetrathiomolybdate, and rapamycin, as well as Lupron, Casodex, Avodart, and Proscar.
Washington, Mar 20 (ANI): Cough medicine ingredient
noscapine could be used as a prophylactic treatment for prostate cancer, according to a new study.
The Opium Poppy is the type of poppy from which opium and many refined opiates, including morphine, thebaine, codeine, papaverine, and
noscapine, are extracted.
Genotoxicity evaluation of morphine, buprenorphine, pentazocine and
noscapine by micronucleus assay & comet assay in mice.