The absence of AZFb is associated with maturation arrest at meiosis, whereas micro-deletion of AZFc results in variable clinical and histologic phenotypes, ranging from
oligozoospermia to SCOS (6).
Literature search: In an attempt to retrieve the original English and Farsi language articles about the frequency of Y chromosome microdeletions among Iranian infertile men with azoospermia or severe
oligozoospermia, a systematic search was performed on international and Iranian databases including PubMed, Scopus, Web of Science, Google Scholar, IranMedex (iranmedex.com), MEDLIB (medlib.ir), IranDoc (irandoc.ac.ir), and Scientific Information Database (sid.ir).
This results in both gross reduction of spermatogenesis leading to
oligozoospermia or azoospermia and/or functional defects in sperm if present leading to primary male infertility that we can call Y-chromosome infertility.
All but two had an azoospermia, patients number 2 and 4 presented an extreme
oligozoospermia, less than 0.8x 106/ml.
The study also confirmed that [DELTA]mtDNA affected mitochondrial respiration chain function and resulted in
oligozoospermia, asthenozoospermia and teratozoospermia leading to infertility in mice.
The prevalence of chromosomal aberrations is dependent on the definition of 'infertility', and is approximately 2% in males with combined indications of infertility (9), 5% in men with
oligozoospermia and 14% with azoospermia (10).
Oligozoospermic had low sperm counts which had further two subdivisions;
Oligozoospermia coupled with abnormal motility, group was referred to as Oligoasthenozoospermia.
The most common causes of infertility were male factors (n=6) consisting of
oligozoospermia (n=3), oligoasthenozoospermia (n=2) and teratozoospermia (n=1) cases, followed by polycystic ovary syndrome (PCOS) (n=5), unexplained infertility (n=3) and endometriosis (n=2) cases.
Sperm transcriptome profiling in
oligozoospermia. J Assist Reprod Genet 2012;29(1):3-10.
Effect of protodioscin on the quantity and quality of sperms from males with moderate idiopathic
oligozoospermia. Medika 1996;22(8):614-8.
Up to 30-40% of patients may have ongoing
oligozoospermia or azoospermia after an acute episode of epididymo-orchitis lasting up to 2 years (38).
[5.] Zhou-Cun A, Yang Y, Zhang SZ, Zhang W, Lin L (2006) Chromosomal abnormality and Y chromosome microdeletion in Chinese patients with azoospermia or severe
oligozoospermia. Yi Chuan Xue Bao 33: 111-116.