Osteoblast specific gene expression detected by RTPCR.
The BMP receptors are a family of transmembrane serine/threonine kinases that include the type I receptors Bmpr1a and Bmpr1b , and the type II receptor Bmpr2 .[20] Deletion of the receptor Bmpr1a in the
osteoblast lineage cells with a Dmp1 -Cre caused a dramatic increase in trabecular bone mass in postnatal mice, which was due to a marked increase in
osteoblast numbers.
Type I collagen, alkaline phosphatase, and calcium deposition are well-known molecular markers for
osteoblast maturity.
[15] (GSE54461, nine time points: 2, 4, 6, 8, 10, 12, 14, 16, and 18 days of
osteoblast differentiation).
Osteoblast Supports T Cell Differentiation and HSC Function.
The result indicated that [gamma]-tocotrienol at low dosage could indirectly regulate the activation of
osteoblast proliferation and was consistent with MTT results.
In a recent study, it was also shown to inhibit ST2 cell differentiation toward the osteogenic linage by directly targeting lysine-specific demethylase 6b (Kdm6b), a regulator of
osteoblast differentiation [46].
Bone is a dynamic tissue in which three cell types, osteoclasts,
osteoblasts and osteocytes, regulate its homeostasis by constant resorption and deposition of the mineral components and structural realignment and remodeling of its matrix in response to biochemical and mechanical signals.
Transcriptional mechanisms in
osteoblast differentiation and bone formation.