The
osteocytes completely occupied the lacunae and developing Havers's canals were seen (Fig.
(2012)
Osteocyte RANKL: new insights into the control of bone remodeling.
This finding may be due to a negative feedback of the inflammatory mediators on the
osteocyte growth and multiplication.
PTH signaling in osteoprogenitors, instead of osteoblasts and
osteocytes, is indispensable for B cell differentiation [33].
Manolagas, "Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts end
osteocytes by glucocorticoids potential mechanisms of their deleterious effects on bone," Journal of Clinical Investigation, vol.
Osteonecrosis (ON), which involves the physiological remodeling of bone tissues [1], is thought to be caused by interruptions in blood flow, a decline in the function/number of osteoprogenitor cells, and apoptosis of the
osteocytes [2-10].
Osteocytes originated from the endosteal surface do not participate in forming repair tissues.
Furthermore,
osteocytes utilize GJIC to coordinate bone remodeling in response to anabolic factors and mechanical loading.
Bonewald, "The
osteocyte: an endocrine cell and more," Endocrine Reviews, vol.