As a result of the large doses for extended periods of time, irrational behavior may occur, as well as fatigue, paranoia, and
psychotomimetic symptoms [24,101,117].
REL-1017 (dextromethadone) is an orally administered NMDA receptor (NMDAR) antagonist, which is active on the NMDAR ketamine binding site and has demonstrated an overall favorable safety profile without ketamine
psychotomimetic adverse reactions in two Phase 1 studies.
Impact of cannabidiol on the acute memory and
psychotomimetic effects of smoked cannabis: naturalistic study.
WAY 100135, an antagonist of 5-HT1A serotonin receptors, attenuates
psychotomimetic effects of MK-801.
Svensson TH: Dysfunctional brain dopamine systems induced by
psychotomimetic NMDA-receptor antagonists and the effects of antipsychotic drugs.
Most conventional nonselective NMDA receptor antagonists, however, have been implicated in adverse effects including
psychotomimetic effects, impairments of learning, memory, and dissociative anesthesia.
Dysphoric reaction are less frequent and my include anxiety, fear, and
psychotomimetic symptoms, but these effects are generally transient and usually do not need medical intervention (16,18,20,21).
Unlike ketamine, GLYX-13 does not elicit
psychotomimetic side effects.
Seibyl et al., "Subanesthetic effects of the noncompetitive nmda antagonist, ketamine, in humans:
psychotomimetic, perceptual, cognitive, and neuroendocrine responses," Archives of General Psychiatry, vol.
The link between glutamate, NMDAR, and schizophrenia was firstly suggested by
psychotomimetic symptoms induced by NMDAR noncompetitive antagonists, such as ketamine and phencyclidine, in healthy subjects [16].