The search used the names of the pyrogenic substances in Annex G of ISO 10993-11 as listed in Table 1 coupled with one or more of the following keywords: medical device,
pyrogen, ISO 10993, nanomaterial, nanoparticle.
The Rabbit
Pyrogen (Material Mediated) - ISO Test was performed by Toxikon Corporation in Bedford, Massachusetts, USA.
Any significant increase in the temperature is indicative of
pyrogens. Hitherto the sole alternative was the Limulus amebocyte lysate (LAL) test.
The report
Pyrogen Testing Market by Product (Instruments, Services, Kits and Reagents), Application (Pharmaceutical & Biotechnology, Medical Devices, Other), & by Test (In Vitro, LAL, Gel Clot, Turbidimetric, Chromogenic, Rabbit) - Global Forecasts to 2021 provides a detailed overview of the major drivers, restraints, opportunities, current market trends, and strategies impacting the global
pyrogen testing market along with the estimates and forecasts of the revenue and market share analysis.
Infectious fever is the defensive and adaptive reaction that occurs when an organism's immune system comes into contact with exogenous
pyrogens, or pathogen-associated molecular pattern (PAMP).
Leptospira interrogans serogroup Autumnalis, canicola, grippotyphosa, icterohaemorrhagiae, pomona and
pyrogens are used in this study.