Structure and function of the radical enzyme
ribonucleotide reductase.
Ribonucleotide reductase inhibitors and future drug design.
Ramaswamy et al., "Binding of allosteric effectors to
ribonucleotide reductase protein R1: reduction of active-site cysteines promotes substrate binding," Structure, vol.
Uemura et al., "Combined analysis of intratumoral human equilibrative nucleoside transporter 1 (hENT1) and
ribonucleotide reductase regulatory subunit M1 (RRM1) expression is a powerful predictor of survival in patients with pancreatic carcinoma treated with adjuvant gemcitabine-based chemotherapy after operative resection," Surgery, vol.
HC is a potent inhibitor of the
ribonucleotide reductase and slows down the rate of DNA replication decelerating cell cycle progression at the G1/S phase transition point and elongating the S phase both in vitro and in vivo [3].
Initial screening for EGFR mutation from the lung core needle biopsies was performed with high-affinity class
ribonucleotide analogs termed "locked nucleic acid probes" to identify wild-type EGFR and T790M mutations.
The UL39 gene encodes the large subunit of the
ribonucleotide reductase protein (R1).
Phosphate is the main component of ATP, nucleotide, and
ribonucleotide; thereby, it plays an important role in energy production, nucleic acid, and protein biosynthesis.
In accordance with the notion emerged from the above-mentioned loss-of-function studies suggesting that AMPK activity is anti-inflammatory in nature, both in vitro and in vivo pharmacological activation of this kinase with either AICAR (5-aminoimidazole4-carboxamide
ribonucleotide) or the antidiabetic drugs metformin and troglitazone or the glycolysis inhibitor 2deoxyglucose is associated with marked attenuation of LPS-induced NF[kappa]B activation, as well as iNOS and TNF-[alpha] expression in myocytes, adipocytes, macrophages, neutrophils, and dendritic cells [75-77].
As a typical example, biologically active substances known as a ribonucleic acid /
ribonucleotide extract (RN preparations), derivatives of connective tissue of animals and yeast (Schroeder et al., 1989; Rainsford, 1996).
It has been proposed that the SUV[sub]max of tumors may correlate with the presence or absence of chemotherapy resistance-associated biomarkers based on studies that have displayed a close correlation between SUV[sub]max and the expression levels of excision repair cross-complementary Group 1 (ERCC1)[sup][1] and Tp53-induced glycolysis and apoptosis regulator.[sup][2] FDG avidity of NSCLC and ERCC1 and
ribonucleotide reductase subunit M1 (RRM1) levels have not been as extensively investigated.