Alpha-biphenylsulfonylamino 2-methylpropyl phosphonates: Enantioselective synthesis and
selective inhibition of MMPs.
Wenxin Keli suppresses ventricular triggered arrhythmias via
selective inhibition of late sodium current.
Recently,
selective inhibition of classes I and II HDACs with an inhibitor, trichostatin A (TSA), showed protective effects against MI/R injury [15].
Specifically, in SLE the alternative pathway is preferentially activated, its
selective inhibition being beneficial--probably due to positive effects of the activation of classic and lectin pathway [17, 39].
To confirm the
selective inhibition of CYP1A and 2B6 isoforms by MA, 10 pmol of human recombinant cDNA-expressed CYP1A1,1A2, or 2B6 was incubated with 0.1 -100 [micro]M MA and NGS for 60 min at 37[degrees]C after the addition of 80 pM phenacetin as a selective CYP1A substrate and 50 [micro]M bupropion as a selective CYP2B6 substrate.
(1998)
Selective inhibition of the chymotrypsin-like activity of the 20S proteasome by 5methoxy-1-indanone dipeptide benzamides.
Gierse et al., "Structural basis for
selective inhibition of cyclooxygenase-2 by antiinflammatory agents," Nature, vol.
In addition to natural inhibitors some synthetic inhibitors like endopin 2C modified as serpinendopin 2C show
selective inhibition of cathepsin L compared to papain or elastase [26]; other inhibitors like peptidyl-diazomethyl ketones are also useful irreversible inhibitors for inactivating cysteinyl proteinases in vitro and in vivo more effectively against cathepsin L than cathepsin S [27].
Pirard, "Insight into the structural determinants for
selective inhibition of matrix metalloproteinases," Drug Discovery Today, vol.