[38.] Isobe I, Yanagisawa K, Michikawa M (2000) A possible model of
senile plaques using synthetic amyloid beta-protein and rat glial culture.
Arima, "Regression stage
senile plaques in the natural course of Alzheimer's disease," Neuropathology and Applied Neurobiology, vol.
A[[beta].sub.42] LRP RAGE plaques capillaries capillaries Control 688 172 498 AD 3776 196 648 Significant P < 0.001 ns P < 0.011 difference P-gp eNOS VEGF capillaries capillaries capillaries Control 1279 73 921 AD 920 104 674 Significant ns ns P < 0.035 difference TABLE 3: A[[beta].sub.42]
senile plaque and endothelial vasoactive proteins correlative data.
It is characterized by the gradual buildup of
senile plaques and neurofibrillary tangles in the brain that occurs years before clinical symptoms appear.
However, adverse inflammatory effects, leading to subacute meningoencephalitis, were observed in nearly 6% of the volunteers enrolled in a phase II trial with the AN1792 vaccine, which ended dramatically after the death of one patient despite improvements in the clinical symptoms and reduction of
senile plaques in several other patients (40-43).
Cotman, "[beta]-Amyloid-induced changes in cultured astrocytes parallel reactive astrocytosis associated with
senile plaques in Alzeimer's disease," Neuroscience, vol.
([5]) This may be due to glucose dysregulation, ([4]) accumulation of
senile plaques, metabolic oxidation products associated with hyperglycemia, insufficient action or effect of insulin due to insufficient secretion, activity, or both, ([5]) neuronal damage as a result of advanced glycosylated end product production and oxidative stress, damage to vascular endothelium as a result of high osmotic stress induced by hyperglycemia which disrupts the blood-brain barrier causing local leakage of vascular substances and aggravates neuronal damage.
Subjects with DS also develop
senile plaques and neurofibrillary tangles in the prefrontal and hippocampal cortex with concomitant age-related dementia resembling that observed in Alzheimer's disease (AD).
Teesdale, Copper, Iron and Zinc in Alzheimer's Disease
Senile Plaques. J.