The patients affected by
sialoadenitis show an enlargement of the salivary glands, which can be unilateral (3) or bilateral (4).
Deng et al., "Augmented levels of macrophage and TH1 cell-related cytokine mRNA in submandibular glands of MRL/lpr mice with autoimmune
sialoadenitis," Clinical and Experimental Immunology, vol.
Deshmukh, "Activation of innate immunity accelerates
sialoadenitis in a mouse model for Sjogren's syndrome-like disease," Oral Diseases, vol.
[7] Sublingual salivary gland tumours may mimic lesions like lymphoma, retention cyst, sialolithiasis,
sialoadenitis, etc.
Humby et al., "Activation-induced cytidine deaminase expression in follicular dendritic cell networks and interfollicular large B cells supports functionality of ectopic lymphoid neogenesis in autoimmune
sialoadenitis and MALT lymphoma in Sjoogren's syndrome," Journal of Immunology, vol.
However, nonneoplastic [CD43.sup.+] B-cell populations can be identified in paraffin sections in some circumstances, such as in subepithelial regions of the tonsils, myo/lymphoepithelial
sialoadenitis, atypical marginal zone hyperplasia, as described in children, (9) and in reactive lesions of the terminal ileum (including Peyer patches).
Salivary calculi and chronic
sialoadenitis of the submandibular gland: A radiographic and histologic study.
Tung, "Failure of CD25+ T cells from lupus-prone mice to suppress lupus glomerulonephritis and
sialoadenitis," Journal of Immunology, vol.
Development of malignant lymphoma in myoepithelial
sialoadenitis (Sjogren's syndrome).
The number of associated conditions recognized has increased immensely and includes ulcerative colitis, Crohn disease, primary sclerosing cholangitis, (56-60) lymphoplasmacytic cholecystitis, (16) primary biliary cirrhosis, (61) Sjogren syndrome, (3,62) chronic sclerosing
sialoadenitis resembling Mikulicz disease, (45,63) thyroiditis, (64) the family of tumorlike lesions known as multifocal idiopathic fibrosclerosis, including mediastinal and retroperitoneal fibrosis, Riedel thyroiditis, and inflammatory pseudotumor of the orbit, (65-70) tubulointerstitial nephritis, (71-73) interstitial pneumonia, (74) lymphadenopathy, (75) prostatitis, (76) and inflammatory abdominal aortic aneurysm.