Sulfasalazine, 5-aminosalicylic acid (5-ASA, mesalamine), sulfapyridine, and capsaicin were purchased from Sigma (St.
Sulfapyridine was initially dissolved in dimethyl sulfoxide (DMSO) and then diluted to 10% DMSO in PBS.
To a solutions of (1.993 g, 0.008 mol)
sulfapyridine dissolved in 100 ml absolute EtOH (1.608 gr, 0.008 mol) 5-bromosalicylaldehyde dissolved in 10 ml absolute EtOH (for L1H), (1.336 gr, 0.008 mol) 5-nitrosalicylaldehyde dissolved in 10 ml absolute EtOH (for L2H) were added dropwise at 78 AdegC with continuous stirring for 6h.
It is split by intestinal bacteria into
sulfapyridine and 5-aminosalicylic acid.
The sulfa drugs sulfanilamide,
sulfapyridine, and sulfathizole prepared by organic chemistry students were tested in microbiology experiments.
It crops components of 5-acetyl salicylic acid and sulfapyridine. Side effects such as reversible sperm abnormalities, pancreatitis, hepatitis, hemolytic anemia (more common in glucose 5-phosphate dehydrogenase deficiency), lung disease, rash, nausea, weakness, and fever can be seen.
Sulphasalazine is separated into sulfapyridine and 5-acetyl salicylic acid after oral administration, and sulfapyridine acetylation is catalyzed by the N-acetyltransferase-2 enzyme in the liver.