Germline mutation of the
telomerase reverse transcriptase gene
* To study the correlation between oxidative stress (Malondialdehyde, Glutathione S Transferase) with telomere dysfunction (telomere length and
telomerase activity) in hypertensive male patients.
But what you may not know is that these aren't the best nutrients for increasing
telomerase. There are other less popular nutrients that are actually more effective
telomerase enhancers.
So far, attempts to efficiently block
telomerase in cancer have not been fruitful in the clinic.
Part protein and part RNA -- genetic material that relays instructions for building proteins --
telomerase acts on microscopic sheaths, known as telomeres, that cover the tips of the chromosomes found inside all cells.
In order to really take advantage of
telomerase, scientists have been studying this complex enzyme in more detail to better understand its structure.
Counteracting the telomere shrinking process is the enzyme
telomerase that uniquely holds the key to delaying or even reversing the cellular aging process.
As we can see from Figure 1, both TL (T/S ratio) and
telomerase activity were positively correlated with week of gestation (T/S ratio, Pearson correlation r = 0.47, p = 0.03;
telomerase activity, r = 0.72, p = 0.0002).
They found that
telomerase was able to add a damaged DNA precursor molecule to the end of the telomere, but was then unable to add additional DNA molecules.
Results: For all patients, no significant difference was found in mRNA expressions of human
telomerase reverse transcriptase and dyskerin (p>0.05), although their levels in tumour tissues were found to be higher than in normal tissues.
We also report that withaferin A can inhibit the STAT3 activation, reduce the stem cell-like traits, and decrease the
telomerase activity.
In a more generalized study, vitamin D supplementation in a group of overweight Americans, at a dose of 2000 IU/day, increased subjects'
telomerase activity by more than 19%.