Concordance of results between QuantiFERON-TB Gold In-Tube Test and
tuberculin skin test QFT-GIT QFT-GIT K (+) (-) Overall n=138 TST(+) 22 8 0.59; 95% CI 0.43-0.75 TST(-) 12 96 No IMS n=40 TST(+) 9 0 0.75, 95% CI 0.52-0.97 TST(-) 4 27 IMS n=98 TST(+) 13 8 0.51, 95% CI 0.30-0.72 TST(-) 8 69 QFT-GIT: QuantiFERON-TB Gold In-Tube Test; TST:
tuberculin skin test; IMS: immunosuppressant; CI: confidence interval Table 3.
Traditional
tuberculin skin test (TST) has been used for over a hundred years as the diagnostic test, but it has several limitations.
TB assay and
tuberculin skin test for the evaluation of young children at high risk for tuberculosis in a community setting," Pediatrics, vol.
Tuberculin skin test showed an induration of more than or equal to 10 mm in 274(34%) cases which was highest in Baluchistan.
Tuberculin skin test, immunoglobulins and skin prick test were found to be normal.
Utilization of the QuantiFERON-TB Gold test in a twostep process with the
tuberculin skin test to evaluate health care workers for latent tuberculosis.
However, correlative
tuberculin skin tests did not produce the obvious skin responses usually observed in mammalian and avian species.
National and international guidelines have consistently recommended INH prophylaxis given for 6 months in children under 5 years of age or HIV-infected children of any age, who are exposed to a household TB contact or have a positive
tuberculin skin test.
Tests for HIV and
tuberculin skin test were also negative.
The
tuberculin skin test (TST), on the other hand, measures immune response or cell-mediated hypersensitivity to tuberculin purified protein derivative (PPD), a polyvalent antigenic mixture of proteins derived from M.
Scientific surveys -- based on
tuberculin skin test -- have shown that nearly one third of the global population is latently infected with the tuberculosis germ -- Mycobacterium tuberculosis ( Mtb).