abasia

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abasia

[ā′bā·zhə]
(medicine)
Lack of muscular coordination in walking.
References in periodicals archive ?
The critical differences are due to the properties of the DNA poly merase used and whether it can read through uracil and/or through abasic sites.
Both providers remain strong cash flow generators, despite the recession thanks to their massive retail subscriber bases, the abasic need' nature of mobile voice service, sound cost control and reasonable investment policies.
An Isa, or Individual Savings Account, should be your first choice for any spare cash if you're abasic or higher rate taxpayer.
SSB Endo III sites, reflecting abasic sites and oxopyrimidines, were evaluated by a modified version of comet assay with Endo III treatment (Collins et al.
In addition, destabilization of the sense strand through other modifications such as non-canonical bases, mismatches, and abasic sites at strategic regions also played a role in improving siRNA potency in vitro.
Finally, we have recently described a combined PCR and sequencing method that, although useful for some applications, requires the use of a specially modified primer (containing an abasic region and a long thymidine tail) and is somewhat limited in the length of sequencing data that can be generated (15).
Apurinic/apyrimidinic (AP) endonuclease 1 (Ape1) is the major mammalian abasic endonuclease and initiates repair of this cytotoxic/mutagenic lesion by incising the DNA backbone via a [Mg.
The mixture was incubated at 37[degrees]C for 3 h and then at 95[degrees]C for 30 min to denature DNA with abasic sites and inactivate the uracil N-glycosylase and shrimp alkaline phosphatase.
Inhibition of AP endonuclease by lucanthone leads to the accumulation of abasic sites in DNA that are converted to lethal double-strand breaks leading to sensitization of tumor cells to alkylating agents and to radiation.
In addition, the generation of alkali-labile abasic sites might account for at least part of the persistent DNA damage in heart cells.