acetylcholine

acetylcholine (əsēt'əlkō`lēn), a small organic molecule liberated at nerve endings as a neurotransmitter. It is particularly important in the stimulation of muscle tissue. The transmission of an impulse to the end of the nerve causes it to release neurotransmitter molecules onto the surface of the next cell, stimulating it. After such release, the acetylcholine is quickly broken into acetate and choline, which pass back to the first cell to be recycled into acetylcholine again. The poison curare acts by blocking the transmission of acetylcholine. Some nerve gases operate by preventing the breakdown of acetylcholine causing continual stimulation of the receptor cells, which leads to intense spasms of the muscles, including the heart. Acetylcholine is often abbreviated as Ach. See nervous system.

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acetylcholine

Ester of choline and acetic acid, a neurotransmitter active at many nerve synapses and at the motor end plate of vertebrate voluntary muscles. It affects several of the body's systems, including the cardiovascular system (decreases heart rate and contraction strength, dilates blood vessels), gastrointestinal system (increases peristalsis in the stomach and amplitude of digestive contractions), and urinary system (decreases bladder capacity, increases voluntary voiding pressure). It also affects the respiratory system and stimulates secretion by all glands that receive parasympathetic nerve impulses (see autonomic nervous system). It is important in memory and learning and is deficient in the brains of those with late-stage Alzheimer disease.