acetylcholine receptor


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acetylcholine receptor

[ə‚sed·əl ′kō‚lēn ri‚sep·tər]
(cell and molecular biology)
A receptor in the membranes of certain cell structures, such as synapses or the neuromuscular junction, to which the transmitter substance acetylcholine binds. Nicotinic acetylcholine receptors are gated ion channels that open in response to acetylcholine, leading to an increase in membrane conductance; muscarinic acetylcholine receptors are G-protein-linked receptors inducing membrane ion channel changes or intracellular processes such as smooth muscle contraction.
References in periodicals archive ?
However, the fact that atropine, an antagonist of muscarinic acetylcholine receptors (18), did not modify the direct vasorelaxation produced by clobenzorex on rat aortic segments excludes the possible involvement of stimulation of muscarinic acetylcholine receptors in the vasodilator responses produced by this appetite suppressant drug.
Keywords included synonyms of "schizophrenia", "[alpha]7-nicotinic acetylcholine receptor agonist", and "cognitive dysfunction" (and the Chinese equivalents).
In these patients, we found autosomal dominant inheritance of a heterozygous mutation in acetylcholine receptor epsilon-subunit ( CHRNE ) gene.
Does change in acetylcholine receptor antibody level correlate with clinical change in myasthenia gravis?
Effects of blockade of [alpha]4[beta]2 and [alpha]7 nicotinic acetylcholine receptors on cue-induced reinstatement of nicotine-seeking behaviour in rats.
More than 10 nicotinic acetylcholine receptor genes have been cloned in insects and post-translational modifications have been observed on subunit mRNAs (Grauso et al.
1985) Purification of the muscarinic acetylcholine receptor from porcine brain.
dorsalis, we report the cloning and characterization of the nicotinic acetylcholine receptor alpha6 cDNA and the expression patterns at different developmental stages and in different tagmata of adult flies using quantitative real-time PCR.
This active ingredient regulates epidermal homeostasis by controlling calcium inflow into keratinocytes via the nicotinic acetylcholine receptor (nAChRs) pathway, according to the company.
A final consideration is the potential influence of repeated exposure to suxamethonium, however we are not aware of any direct action of suxamethonium upon acetylcholine receptor regulation.
Her dissertation entitled The role of nicotinic acetylcholine receptor a4~32 and cz7 in nicotine-ethanol interaction and cross-tolerance: Functional correlation with cerebellar nitric oxide.
Detection of autoantibodies to the neuromuscular nicotinic acetylcholine receptor (ACHR) has proved useful in assisting in the diagnosis of MG; however, the complexity of this disease, combined with the variety of antibodies associated with MG, has led to multiple attempts to correlate disease severity with antibody detection and concentration.