Acinus

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Related to acinic: Acinic cell carcinoma

acinus

[′as·ə·nəs]
(anatomy)
The small terminal sac of an acinous gland, lined with secreting cells.
(botany)
An individual drupelet of a multiple fruit.

Acinus

 

(1) A structural and functional unit or the terminal secretory portion of the salivary, pancreatic, lacteal, sebaceous, or other saccular (alveolar) glands. The acinus is a bubble-like formation of one or more types of gland cells situated on a basement membrane and surrounded by connective tissue, capillaries, and nerve fibers. The apexes of the cells with their microvilli are directed toward the chamber of the acinus into which the secretion is discharged.

(2) A part of the respiratory apparatus in mammals that includes a section of the lung corresponding to the branches of the terminal bronchus—that is, the bronchioles, alveolar passages, and alveoli. One pulmonary lobule consists of 12–18 acini.

References in periodicals archive ?
Helioid inclusions in dedifferentiated acinic cell carcinoma of the parotid gland.
Acinic cell carcinoma of palate a rare presentation.
Dedifferentiated acinic cell (acinous) carcinoma of the parotid gland.
12) In their survey of patients younger than 20 years, Byers et al found a 5-year survival rate of 50% in patients with acinic cell carcinoma, including high-grade tumors.
Acinic cell carcinoma of the salivary glands: A literature review.
Acinic cell carcinomas account for approximately 6% of all salivary gland neoplasms and are the fourth most common salivary malignant neoplasm, following mucoepidermoid carcinomas, adenocarcinoma not otherwise specified, and adenoid cystic carcinoma.
2-4) With regard to the prevalence of parotid gland cancers in children, acinic cell carcinoma is second only to mucoepidermoid carcinoma.
According to sources cited by Kim and Mathog, mortality from acinic cell carcinoma at 20 years is as high as:
The differential diagnosis of clear cell salivary neoplasias encompasses a broad range of possibilities, including primary salivary clear cell tumors, such as clear cell carcinoma (CCC), epithelial-myoepithelial carcinoma (EMEC), and clear cell myoepithelioma/myoepithelial carcinoma (CCMEC), as well as clear cell variants of other salivary tumors, including acinic cell carcinoma, oncocytoma, and mucoepidermoid carcinoma.
Histologically distinctive (although one of the few cases published in this location was reported as acinic cell carcinoma at intraoperative consultation),[6] the differential diagnosis with oncocytic cell tumors or other lesions of the salivary gland that can be composed at least partially by cells of granular cytoplasm, might be difficult, especially on fine-needle aspiration biopsy smears.
Frozen sections are often unreliable because they have difficulty distinguishing a renal carcinoma from an oncocytoma, an odontogenic tumor, and an acinic cell, thyroid, and lung carcinoma.