aconitase


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aconitase

[ə′kän·ə‚tās]
(biochemistry)
An enzyme involved in the Krebs citric acid cycle that catalyzes the breakdown of citric acid to cis-aconitic and isocitric acids.
References in periodicals archive ?
To determine paternal ancestry, we amplified a portion of the Z-chromosome aconitase intron 9 using primers ACO-I10F and ACO-I10R2 and a step-down PCR protocol described by Vallender et al.
34) Its actions inactivate mitochondrial aconitase and alcohol dehydrogenase, as well as several other enzymes critical in metabolic function.
According to the detected genes for glucose metabolism, they elucidated the fungal carbohydrate metabolism pathway and postulated that the metabolites for Neocallimastix frontalis were acetate, ethanol, formate, lactate, succinate and a-ketoglutarate, which was oxidized from oxaloacetate by aconitase and isocitrate dehydrogenase.
It is confirmed by studies reported age-dependent inactivation of mito-chondrial aconitase which is the primary target of superoxide and may contribute to aging and death in yeast (Fabrizio et al.
ATX antagonized ischemia-mediated loss of aconitase activity and reduced glutamate release, lipid peroxidation, translocation of cytochrome c, and TUNEL labeling in the ischemic cortex.
To assess mitochondrial oxidant load, we quantified aconitase activity from mitochondrial isolates [see Supplemental Material, page 7 (doi:10.
2 Converts Fe+1 to (TSAP6) Fe+2 in endosomes IRP1 100880 1RP1 9p22-pl3 Bifunctional (ACOl) protein, acts as aconitase or iron response protein due to cellular iron levels IRP2 147582 IRP2 15q25.
Temperature-dependent effects of cadmium and purine nucleotides on mitochondrial aconitase from a marine ectotherm, Crassostrea virginica: a role of temperature in oxidative stress and allosteric enzyme regulation.
System 11 was used to resolve aconitase (Aco-1, Aco-2), diaphorase (Dia-1, Dia-2, Dia-3, Dia-4), isocitrate dehydrogenase (Idh-1), and shikimic dehydrogenase (Skdh-1).
Thus NO inhibits tobacco aconitase and iron-sulphur-containing enzyme that catalyzes the isomerisation of citrate to isocitrate (Navarre et al.
STRUCTURAL STUDIES OF HUMAN MITOCHONDRIAL ACONITASE.
The IRP1 was soon recognized as counterpart of mitochondrial aconitase due to its ability to assemble a [Fe-4S] cluster (48).