acriflavine


Also found in: Dictionary, Medical, Wikipedia.
Related to acriflavine: acriflavine hydrochloride

acriflavine

[‚ak·rə′flā‚vēn]
(organic chemistry)
C14H14N3Cl A yellow acridine dye obtained from proflavine by methylation in the form of red crystals; used as an antiseptic in solution.
References in periodicals archive ?
Reference drugs included sodium stibogluconate (Pentostam; Sigma), amphotericin B (Fungizone; Squib), pentamidine isethionate (Sigma), trifluralin (Sigma) and acriflavine (Sigma).
BALB/c mice-treated using acriflavine and trifluralin produced significantly larger lesion sizes than those being treated using saponin and plumbagin.
2 mg/kg dose of saponin, plumbagin, trifluralin and acriflavine resulted in 97.
In the initial testing for the antileishmanial activity of independent drugs the order of potency was as follows in decreasing strength: saponin (Sap) >Plumbagin (Plgn) > Trifluralin (Tri) > Acriflavine (Acri).
05) higher parasite load in the liver and spleen occurred in acriflavine/plumbagin combination followed by trifluralin/plumbagin and the lowest LDU occurred in the trifluralin and acriflavine combination therapies.
Com bined therapy of saponin and acriflavine was the most effective in reducing both the lesion sizes and hepatic parasite load; followed by saponin & plumbagin; trifluralin & acriflavine; trifluralin & saponin; trifluralin & plumbagin and acriflavine & plumbagin combinations.
There was a remarkable long-term in vivo activity of trifluralin, acriflavine, saponin and plumbagin at 1.
They then tested each of the more than 3,000 drugs in the John Hopkins drug library and found that Acriflavine did turn out the light and further studies confirmed that it was binding directly to HIF-1.
Liu hopes that acriflavine can one day be incorporated into chemotherapy cocktails, one drug among many that help fight cancer.