acromegaly

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Related to acromegalic: acromegalic gigantism

acromegaly

(ăk'rōmĕg`əlē), adult endocrine disorder resulting from hypersecretion of growth hormone produced by the pituitary gland. Since the bones cannot increase in length after full growth is attained, there is a disproportionate thickening of bones, predominantly in the skull and small bones of the hands and feet. Fingers and toes become broadened and spadelike, the skull increases in size, and the cheek bones and jaws protrude. Many of the soft tissues, such as the tongue and liver, enlarge. Frequently glucose metabolism is disturbed, leading to diabetes mellitus. Acromegaly is usually caused by a tumor of the pituitary; treatment consists of irradiation or surgical removal of the tumor. Onset of the disease can also occur in children, before the epiphyses of the bones are closed. In such cases the disorder leads to gigantismgigantism,
condition in which an animal or plant is far greater than normal in size. Plants are often deliberately bred to increase their size. However, among animals, gigantism is usually the result of hereditary and glandular disturbance.
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Acromegaly

 

a disease associated with disruption of the functioning of the anterior lobe of the hypothesis (adenohypophysis); it is accompanied by enlargement (broadening and thickening) of the wrists, feet, skull (especially the facial portion), and other parts. Acromegaly usually appears following maturation; its development is gradual, extending over many years. It is the result of excessive production of somatotropin. Analogous disruption of hypophysis activity in immature individuals is called gigantism. Acromegaly is accompanied by cephalalgia, fatigability, weakening of intellectual capacity, visual disorders, and frequently sexual impotence in men and amenorrhea in women. Its treatment consists of surgery of the hypophysis or roentgenotherapy.

REFERENCES

Baranov, V. G. Bolezni endokrinnoi sistemy i obmena veshchestv, 2nd ed. Moscow, 1955.
Rukovodstvo po klinicheskoi endokrinologii. Edited by E. A. Vasiukova. Moscow, 1958.

acromegaly

[‚ak·rō′meg·ə·lē]
(medicine)
A chronic condition in adults caused by hypersecretion of the growth hormone and marked by enlarged jaws, extremities, and viscera, accompanied by certain physiological changes.
References in periodicals archive ?
Reversibility of joint thickening in acromegalic patients: an ultrasonography study.
The differential diagnosis of a patient with acromegalic features but normal plasma GH and IGF-1 levels includes pseudoacromegaly (5).
In the phase IIa study, the exposure to BIM 23A760 in acromegalic patients, exhibited a 66-74% mean maximum reduction in growth hormone (GH) levels.
Presently, there is no warning against the risks of this grave situation in acromegalic patients in current applied guidelines.
A Phase 2 Exploratory Study of BIM 23A760 in Acromegalic Patients: Preliminary Results of Safety and Efficacy after a Single-dose Administration
In the literature, apoplexy in acromegalic patients is often reported to be associated with precipitating factors (4-10).
Acromegalic patients exhibit many features of the metabolic syndrome, including arterial hypertension, insulin resistance, and a high frequency of macrovascular complications.
Somatuline([R])Depot is currently approved in the United States for the long-term treatment of acromegalic patients who have had an inadequate response to, or cannot be treated with, surgery and/or radiotherapy.
This partnership allows Ipsen to further strengthen its position in endocrinology, and illustrate our commitment to offer state of the art treatment to acromegalic patients and to provide endocrinologists with optimal therapeutic choices" said Jacques-Pierre Moreau, Executive Vice-President, Chief Scientific Officer of Ipsen.
Long-term maintenance therapy in acromegalic patients who have had inadequate response to surgery and/or radiotherapy or for whom surgery and/or radiotherapy is not an option (the goal of treatment in acromegaly is to reduce GH and IGF-1 levels to normal).