acromegaly


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acromegaly

(ăk'rōmĕg`əlē), adult endocrine disorder resulting from hypersecretion of growth hormone produced by the pituitary gland. Since the bones cannot increase in length after full growth is attained, there is a disproportionate thickening of bones, predominantly in the skull and small bones of the hands and feet. Fingers and toes become broadened and spadelike, the skull increases in size, and the cheek bones and jaws protrude. Many of the soft tissues, such as the tongue and liver, enlarge. Frequently glucose metabolism is disturbed, leading to diabetes mellitus. Acromegaly is usually caused by a tumor of the pituitary; treatment consists of irradiation or surgical removal of the tumor. Onset of the disease can also occur in children, before the epiphyses of the bones are closed. In such cases the disorder leads to gigantismgigantism,
condition in which an animal or plant is far greater than normal in size. Plants are often deliberately bred to increase their size. However, among animals, gigantism is usually the result of hereditary and glandular disturbance.
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Acromegaly

 

a disease associated with disruption of the functioning of the anterior lobe of the hypothesis (adenohypophysis); it is accompanied by enlargement (broadening and thickening) of the wrists, feet, skull (especially the facial portion), and other parts. Acromegaly usually appears following maturation; its development is gradual, extending over many years. It is the result of excessive production of somatotropin. Analogous disruption of hypophysis activity in immature individuals is called gigantism. Acromegaly is accompanied by cephalalgia, fatigability, weakening of intellectual capacity, visual disorders, and frequently sexual impotence in men and amenorrhea in women. Its treatment consists of surgery of the hypophysis or roentgenotherapy.

REFERENCES

Baranov, V. G. Bolezni endokrinnoi sistemy i obmena veshchestv, 2nd ed. Moscow, 1955.
Rukovodstvo po klinicheskoi endokrinologii. Edited by E. A. Vasiukova. Moscow, 1958.

acromegaly

[‚ak·rō′meg·ə·lē]
(medicine)
A chronic condition in adults caused by hypersecretion of the growth hormone and marked by enlarged jaws, extremities, and viscera, accompanied by certain physiological changes.
References in periodicals archive ?
Octreotide, a somatostatin analog that suppresses excessive growth hormone production from pituitary adenomas, is the mainstay of medical management of acromegaly.
The company said acromegaly is most often caused by a benign pituitary adenoma and is characterised by clinical features including enlargement of the hands and feet, facial changes, hypertension, diabetes mellitus and cardiomyopathy.
He also highlighted the efficacy of Lanreotide in acromegaly besides monotherapy with SSA.
In contrast to GH's pulsatile secretion and rapidly changing concentrations in the circulation, serum concentrations of IGF-I are stable, making it a valuable marker for diagnosis of acromegaly and for long-term monitoring of its treatment.
The blood antioxidant system is impaired in patients with active acromegaly, what indicates the development of oxidative stress [7].
Acromegaly is a rare disease caused by excess secretion of Growth Hormone (GH) and Insulin-like Growth Factor (IGF)-I from a pituitary adenoma (1).
We present the case of a 66 year old woman known with acromegaly, since 1983 (pituitary GH macroadenoma).
The report reviews key players involved in the therapeutics development for Acromegaly and enlists all their major and minor projects
In the early period, arthralgia is seen in 70% of acromegaly patients, commonly involving the hip, knee, ankle and wrist joints.
In these patients, acromegaly is a condition which is differentiated from classical acromegaly cases with early-onset facial asymmetry and hyperprolactinemia in association with FD and pituitary imaging findings which does not necessarily reveal presence of a prominent adenoma.
Acromegaly was ruled out with the finding of normal GH and IGF-1 levels in this patient.
GlobalData epidemiologists forecast an increase in the diagnosed prevalent cases of acromegaly in the 6MM from 25,354 diagnosed prevalent cases in 2013 to 26,884 diagnosed prevalent cases in 2023, at an Annual Growth Rate (AGR) of 0.