acromegaly


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acromegaly

(ăk'rōmĕg`əlē), adult endocrine disorder resulting from hypersecretion of growth hormone produced by the pituitary gland. Since the bones cannot increase in length after full growth is attained, there is a disproportionate thickening of bones, predominantly in the skull and small bones of the hands and feet. Fingers and toes become broadened and spadelike, the skull increases in size, and the cheek bones and jaws protrude. Many of the soft tissues, such as the tongue and liver, enlarge. Frequently glucose metabolism is disturbed, leading to diabetes mellitus. Acromegaly is usually caused by a tumor of the pituitary; treatment consists of irradiation or surgical removal of the tumor. Onset of the disease can also occur in children, before the epiphyses of the bones are closed. In such cases the disorder leads to gigantismgigantism,
condition in which an animal or plant is far greater than normal in size. Plants are often deliberately bred to increase their size. However, among animals, gigantism is usually the result of hereditary and glandular disturbance.
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Acromegaly

 

a disease associated with disruption of the functioning of the anterior lobe of the hypothesis (adenohypophysis); it is accompanied by enlargement (broadening and thickening) of the wrists, feet, skull (especially the facial portion), and other parts. Acromegaly usually appears following maturation; its development is gradual, extending over many years. It is the result of excessive production of somatotropin. Analogous disruption of hypophysis activity in immature individuals is called gigantism. Acromegaly is accompanied by cephalalgia, fatigability, weakening of intellectual capacity, visual disorders, and frequently sexual impotence in men and amenorrhea in women. Its treatment consists of surgery of the hypophysis or roentgenotherapy.

REFERENCES

Baranov, V. G. Bolezni endokrinnoi sistemy i obmena veshchestv, 2nd ed. Moscow, 1955.
Rukovodstvo po klinicheskoi endokrinologii. Edited by E. A. Vasiukova. Moscow, 1958.

acromegaly

[‚ak·rō′meg·ə·lē]
(medicine)
A chronic condition in adults caused by hypersecretion of the growth hormone and marked by enlarged jaws, extremities, and viscera, accompanied by certain physiological changes.
References in periodicals archive ?
Median levels of serum PRL (mIU/l) were 3911 in macroadenoma, 1096 in microadenoma, 949 in primary hypothyroidism, 765 in subclinical hypothyroidism, 753 in acromegaly, 700 in idiopathic causes, 620 in PCOS, 449 in cirrhosis and 425 in CKD (Table-1).
In this report, we describe a case of acromegaly, in a patient with MEN-1 with emphasis on screening for GHRH secreting tumors in MEN-1 patients with acromegaly, confirmation of the diagnosis, treatment options and importance of life long surveillance.
For endocrinopathies, 4 out of 5 patients with acromegaly underwent pituitary surgery (2 transfrontal and 2 transsphenoidal) and one with toxic adenoma underwent total thyroidectomy and the other was planned for radioablation.
Reasons listed for using the drug included treatment of enterocutaneous fistula, pancreatic fistula, pituitary macroadenoma, GI hemorrhage, pancreatitis, and acromegaly.
Some common physical characteristics seen in acromegaly are skeletal deformities such as increasing hand and foot size, thickening of the heel pad, frontal bossing, prognathism (a protrusion of the jaw caused by malformations of the bones of the face), and macroglossia (an enlargement of the tongue).
The data from two Japanese trials, one in acromegaly and pituitary gigantism and the other in carcinoid syndrome, were consistent with findings of the previous western Phase III studies that were the basis for approval in the U.
Comment: The goal of treatment with Somavert, which blocks the effects of growth hormone, is to normalize serum levels of IGF-1, a biochemical measure of the severity of acromegaly.
The link between carpal tunnel syndrome and growth hormone replacement therapy and acromegaly remains unclear.
Doreen Oldroyd, of Ansley Village, has acromegaly - an elevated growth hormone level which causes benign tumours.
Carmel, whose extreme size was a result of acromegaly, a disease of giantism, was a frightening mystery, a member of the Carchman family who was never discussed.
High IGF-1 levels are believed to be a cause in humans of acromegaly, a disease that causes an abnormal enlargement of nose, hands, feet and chin.