actinomycin


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actinomycin

(ăk'tənōmī`sən), any one of a group of antibioticsantibiotic,
any of a variety of substances, usually obtained from microorganisms, that inhibit the growth of or destroy certain other microorganisms. Types of Antibiotics
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 produced by bacteria of the genus Streptomyces. Actinomycin was the first antibiotic reported to be able to halt cancer; however, it is not widely used to treat cancers because it is highly toxic to humans, interfering with the genetic material of cells. It is mainly used as an investigative tool in cell biology.

actinomycin

[‚ak·tə·nō′mī·sən]
(microbiology)
The collective name for a large number of red chromoprotein antibiotics elaborated by various strains of Streptomyces.
References in periodicals archive ?
The antitumor antibiotic actinomycin D is a DNA binding agent that has been studied extensively for over thirty years.
The patient was started on radiotherapy (4,500 Gy) and chemotherapy with vincristine, actinomycin D, cyclophosphamide, etoposide, ifosfamide, and melphalan, in accordance with the IRS IV protocol.
Chemotherapy regimens included combinations predominantly of vincristine, cyclophoshamide, etopside, ifosfamide with the addition of doxorubicin, actinomycin, carboplatin and cisplatin.
Among the moderately gonadotoxic agents are cisplatin and adriamycin, while bleomycin, actinomycin D, vincristine, methotrexate, and 5-fluorouracil are associated with mild or no gonadotoxicity (Table 2).
11) The role of chemotherapy is controversial, (16) although Lenoir et a1 (12) reported a dramatic regression in tumor size in a 15-month-old patient with a retropharyngeal synovial sarcoma after treatment with a combination of ifosfamide, vincristine, and actinomycin D.
Lucanthone has structural and biochemical similarities to Actinomycin D but has no hematological or GI toxicity at clinically tolerated doses.
Contract awarded for actinomycin (dactinomycin) 500 mcg road (file efficacy and safety) sulfate / ferrous fumarate 300mg tablet and dimenhydrinate 50 mg / ml vial 5ml.
showed a synergistic growth inhibitory effect with cancer drugs that are Pgp substrates including actinomycin D, puromycin, paclitaxel, vinblastine and doxorubicin.