8,658,765, entitled "Non-Natural MIC Proteins," claims bi-specific, engineered human MIC proteins, termed Micacide(TM) proteins by the company, that simultaneously bind to selected cell surface targets and to the NKG2D activating receptor
expressed on natural killer (NK) cells and certain T cells.
The second platform is focused on the activating receptor
, FcRIIa, implicated in several autoimmune diseases, including rheumatoid arthritis and lupus.
Tony Lam at the Toronto General Research Institute and the University of Toronto discovered that activating receptors
of the cholecystokinin (CCK) peptide hormone in the gut rapidly and potently lowers blood glucose levels by triggering a signal to the brain and then to the liver to lower glucose or sugar production.
They found that versican strongly enhances LLC metastatic growth by activating receptors
that lead to production of cytokines - signaling proteins that regulate the immune system.
When triggered, it delivers an inhibitory signal that contrasts those induced by activating receptors
KDS-2000 is a topical formulation that targets peripheral pain receptors without activating receptors
in the central nervous system thus avoiding the side-effects commonly associated with pain medication.
For almost two decades, Mendelsohn has been at the forefront in understanding how growth factors regulate the proliferation of cancer cells by activating receptors
on the surface of the cells.