The evidence suggesting that CBT is more effective than active controls
or TAU or medication at follow-up is limited and inconclusive.
In 1995 an article in Spine reported that lower back pain occurred less frequently among former elite athletes than less active controls
He says that you cannot use active controls in randomized clinical trials of new drugs because you do not know their precise effect in that particular trial population.
Temple also uses another argument against active controls, namely that we do not have sensitive enough assays in many cases to distinguish the effects of a drug on trial from those of an active control.
During this session the background and implications of including or repurposing active controls in clinical trials was presented.
These trials must include at least two positive short-term studies (6-8 weeks) with both placebo and active controls (for assay sensitivity, distinction of negative and failed studies); and demonstrate statistical significance and clinical relevance (responder rates, e.
Simone also has served in executive management positions at technology firms such as Active Controls
F-16 fighter cockpit complete with realistic, active controls
that ensures the same experience as that of a pilot itself.
Zerenex Significantly Increases Iron Storage Parameters and Decreases Need for Intravenous Iron and Erythropoiesis-Stimulating Agents Versus Active Control
In addition, Zerenex met the key secondary endpoints of increasing ferritin and transferrin saturation (TSAT) and reducing the use of intravenous (IV) iron and erythropoiesis-stimulating agents (ESAs) versus the active control over the 52-week Safety Assessment Period of the study.
The study consisted of a 2-week washout period followed by a 52-week Safety Assessment Period in which subjects were randomized 2:1 to receive either Zerenex or an active control (Renvela[sevelamer carbonate] and/or Phoslo[calcium acetate]).
Zerenex met all the key secondary efficacy endpoints related to iron with statistically significant treatment differences versus the active control group (Renvela[sevelamer carbonate] and/or Phoslo[calcium acetate]), as follows: